MR imaging of the lung using liquid perfluorocarbons.
MR imaging of the lung using liquid perfluorocarbons.
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DOI：
10.1097/00004728-198601000-00001
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发表时间：
1986
影响因子：
1.3
通讯作者：
S. Thomas;L. C. Clark;J. Ackerman;R. Pratt;R. E. Hoffmann;L. J. Busse;R. Kinsey;R. Samaratunga
中科院分区：
文献类型：
--
作者：
S. Thomas;L. C. Clark;J. Ackerman;R. Pratt;R. E. Hoffmann;L. J. Busse;R. Kinsey;R. Samaratunga
某些全氟化碳（PFC）化合物，通常用作“血液替代品”的氧气输送成分，由于其化学惰性和对氧气和二氧化碳的高溶解度，可以作为纯净液体呼吸并存活。此外，氧的顺磁性降低氟T1值，根据一个相反的关系，允许一个潜在的方法，监测体内PO 2梯度。本文报告了小鼠和大鼠吸入四种PFC液体（FC-43、FC-75、PFOB、APF-215）后肺部的磁共振（MR）成像结果。所呈现的图像是在呼吸环境空气或纯氧的条件下在两个磁场强度（0.66和0.14 T）下获得的。PFCs的自旋-晶格弛豫时间（T1）在体外和体内（在肺中）作为氧合状态的函数进行测量。在纯氧呼吸的条件下，在体内证明了高达90%的MR图像信号强度增强。
Certain perfluorocarbon (PFC) compounds, commonly used as the oxygen transport components of "blood substitutes," may be breathed as neat liquids with survival because of their chemical inertness and their high solubility for oxygen and carbon dioxide. In addition, the paramagnetism of oxygen reduces the fluorine T1 value according to an inverse relationship allowing a potential method of monitoring PO2 gradients in vivo. This article presents the results of magnetic resonance (MR) imaging of the lungs of mice and rats following breathing of four PFC liquids (FC-43, FC-75, PFOB, APF-215). The images presented were obtained at two magnetic field strengths (0.66 and 0.14 T) under conditions of breathing either ambient air or pure oxygen. Spin-lattice relaxation times (T1) for the PFCs are measured both in vitro and in vivo (in the lungs) as a function of the state of oxygenation. A MR image signal strength enhancement of up to 90% is demonstrated in vivo under conditions of pure oxygen breathing.