Long-term follow-up of patients with Buerger's disease after autologous stem cell therapy
Long-term follow-up of patients with Buerger's disease after autologous stem cell therapy
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DOI：
10.14744/anatoljcardiol.2018.12354
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发表时间：
2019-03-01
影响因子：
1.3
通讯作者：
Akar, Ruchan
中科院分区：
文献类型：
--
作者：
Baran, Cagdas;Durdu, Serkan;Akar, Ruchan
目的：我们研究了自体骨髓单个核细胞（ABMMNCs）植入Buerger病（BD）患者的长期结果。方法：2003年4月至2005年8月，对28例（男25例，女3例）患有BD和严重单侧肢体缺血的患者进行了研究。患者接受多次注射CD 34+和CD 45 + ABMMNCs到腓肠肌，跖骨间区，足背（n=26）或前臂（n=2）和盐水注射到对侧limb.Results：平均随访时间为139.6 +/- 10.5个月。随访期间未观察到与干细胞治疗相关的并发症。将6个月和120个月时评估的踝臂压力指数与基线评分进行比较（p
Objective: We investigated the long-term results of autologous bone marrow mononuclear cells (ABMMNCs) implantation in patients with Buerger's disease (BD).Methods: Twenty-eight patients (25 males and 3 females) who had BD and critical unilateral limb ischemia were investigated between April 2003 and August 2005. The patients were administered multiple injections of CD34+ and CD45+ positive ABMMNCs into the gastrocnemius muscle, the intermetatarsal region, and the dorsum of the foot (n=26) or forearm (n=2) and saline injection into the contralateral limb.Results: The mean follow-up time was 139.6 +/- 10.5 months. No complication related to stem cell therapy was observed during the follow-up. The ankle-brachial pressure index evaluated at 6 months and 120 months was compared to the baseline scores (p