PRETREATMENT OF RATS WITH PULSED ELECTROMAGNETIC-FIELDS ENHANCES REGENERATION OF THE SCIATIC-NERVE
PRETREATMENT OF RATS WITH PULSED ELECTROMAGNETIC-FIELDS ENHANCES REGENERATION OF THE SCIATIC-NERVE
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DOI：
10.1002/bem.2250140407
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发表时间：
1993-01-01
影响因子：
1.9
通讯作者：
LUNDBORG, G
中科院分区：
文献类型：
--
作者：
KANJE, M;RUSOVAN, A;LUNDBORG, G
研究了脉冲电磁场预处理大鼠坐骨神经的再生。这些大鼠被暴露在一对亥姆霍兹线圈之间，脉冲重复率为2pps，场密度为60或300 muT。然后停止使用PEMF治疗。经过一段时间的恢复，坐骨神经的再生是由挤压损伤引起的。3-6天后，通过“夹头试验”测量感觉纤维的再生情况。各种PEMF预处理，包括4小时/天，持续1-4天或暴露15分钟/天，持续2天，导致挤压损伤后3天测量的再生距离增加。即使在14天的恢复期后，这种效果也可以证明。相比之下，预处理4 h/天，在60 muT下持续2天，对再生距离没有影响。结果表明，PEMF预处理对大鼠坐骨神经的调节作用类似于挤压损伤后的调节作用，表明PEMF对神经元细胞体有影响。然而，这种效应的机制仍然不清楚。(C) 1993 Wiley-Liss, Inc。
Regeneration of the sciatic nerve was studied in rats pretreated in a pulsed electromagnetic field (PEMF). The rats were exposed between a pair of Helmholtz coils at a pulse repetition rate of 2 pps at a field density of 60 or 300 muT. The PEMF treatment was then discontinued. After an interval of recovery, regeneration of the sciatic nerve was initiated by a crush lesion. Regeneration of sensory fibers was measured by the ''pinch test'' after an additional 3-6 days. A variety of PEMF pretreatments including 4 h /day for 1-4 days or exposure for 15 min/day during 2 days resulted in an increased regeneration distance, measured 3 days after the crush lesion. This effect could be demonstrated even after a 14-day recovery period. In contrast, pretreatment for 4 h/day for 2 days at 60 muT did not affect the regeneration distance. The results showed that PEMF pretreatment conditioned the rat sciatic nerve in a manner similar to that which occurs after a crush lesion, which indicates that PEMF affects the neuronal cell body. However, the mechanism of this effect remains obscure. (C) 1993 Wiley-Liss, Inc.