Encephalitis Due to Human Herpesvirus-6B in Pancreas After Kidney (PAK) Transplantation
Encephalitis Due to Human Herpesvirus-6B in Pancreas After Kidney (PAK) Transplantation
复制标题
肾 (PAK) 移植后胰腺中人类疱疹病毒 6B 引起的脑炎
DOI：
10.1111/tid.12270
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发表时间：
2014
影响因子：
2.6
通讯作者：
Kobayashi T.
中科院分区：
文献类型：
--
作者：
Yamamoto T;Watarai Y;Goto N;Horikoshi Y;Yamada S;Yasui K;Tsujita M;Hiramitsu T; Narumi S;Katayama A;Uchida K;Kobayashi T.
人类疱疹病毒- 6 （HHV - 6）是儿童中常见的病原体，典型表现为发烧和皮疹，无需特异性治疗即可消退。HHV - 6可以在免疫抑制患者中重新激活。在骨髓和实体器官移植后，HHV - 6与各种临床综合征有关，包括未分化的发热性疾病、脑炎、脊髓炎、肝炎、肺炎和骨髓抑制。然而，胰腺移植后的HHV - 6脑炎很少有报道。早期诊断和治疗HHV - 6脑炎可能对感染患者很重要。我们报告一例53岁的胰腺肾后移植受者，术后3周出现高热和意识不清。我们设法挽救了病人的生命并保留了胰腺移植的功能。我们还回顾了先前报道的实体器官移植受者的HHV - 6B脑炎病例。
Human herpesvirus‐6 (HHV‐6) is a common pathogen among children, classically presenting with fever and rash that resolves without specific therapy. HHV‐6 can be reactivated in the immunosuppressed patient. After bone marrow and solid organ transplantation, HHV‐6 has been linked to various clinical syndromes, including undifferentiated febrile illness, encephalitis, myelitis, hepatitis, pneumonitis, and bone marrow suppression. However, HHV‐6 encephalitis after pancreatic transplant has rarely been reported. Early diagnosis and treatment of HHV‐6 encephalitis may be important for affected patients. We report the case of a 53‐year‐old pancreas‐after‐kidney transplant recipient who initially presented with high fever and confusion 3 weeks after operation. We managed to save the patient's life and preserve the pancreas graft function. We also review previously reported cases of HHV‐6B encephalitis in solid organ transplant recipients.