Causes and frequency of blindness in patients with intraocular inflammatory disease
Causes and frequency of blindness in patients with intraocular inflammatory disease
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DOI：
10.1136/bjo.80.4.332
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发表时间：
1996-04-01
影响因子：
4.1
通讯作者：
Kijlstra, A
中科院分区：
文献类型：
--
作者：
Rothova, A;SuttorpvanSchulten, MSA;Kijlstra, A
目的/背景-葡萄膜炎是一种眼内炎症性疾病，是视力损害的重要原因。目前尚不清楚有多少葡萄膜炎患者将保留视力，有多少发展为视力障碍甚至失明。本研究的目的是评估葡萄膜炎患者失明的频率，更具体地说，以确定患者的临床资料的风险，为visualloss.Methods-A横截面和回顾性研究的582例葡萄膜炎谁访问了眼科部门的两所大学医院在荷兰进行。203例（35%）患者出现失明或视力障碍; 22例（4%）患者出现双侧法律的盲，26例（4 . 5%）有一只眼睛失明，另一只眼睛视力受损，9（1。5%）有双侧视力损害。单侧失明82例（14%），而64例（11%）表现出单侧视力障碍。失明和视力损害的最重要原因是黄斑囊样水肿（分别为29%和41%）。超过一半的患者出现葡萄膜炎并发症，23%的患者接受了一次或多次手术。当根据解剖部位对患者进行细分时，患有全葡萄膜炎的患者的视力预后最差。与视力预后差相关的全身性疾病是幼年慢性关节炎和结节病。眼弓形虫病是最常见的原因单侧visualloss. Conclusions黄斑囊样水肿是葡萄膜炎的最常见的并发症，其发生起着决定性的作用，这种疾病的视觉结果。
Aims/Background-Uveitis, an intraocular inflammatory disease, is a significant cause of visual impairment. It is not known how many patients with uveitis will retain visual acuity and how many develop visual impairment or even blindness. The aim of this study was to assess the frequency of blindness in patients with uveitis and, more specifically, to identify the clinical profile of patients at risk for visual loss.Methods-A cross sectional and retrospective study of 582 patients with uveitis who visited the ophthalmology departments of two university hospitals in the Netherlands was performed.Results-Within the group of 582 patients, 203 (35%) exhibited blindness or visual impairment; bilateral legal blindness developed in 22 (4%) patients, 26 (4 . 5%) had one blind eye with visual impairment of the other, and nine (1 . 5%) had bilateral visual impairment. Unilateral blindness developed in 82 (14%) patients, whereas 64 (11%) exhibited unilateral visual impairment. The most important cause of both blindness and visual impairment was cystoid macular oedema (29% and 41%, respectively). Complications of uveitis were encountered in more than half of the patients and 23% underwent one or more surgical procedures. When the patients were subdivided according to anatomical site, those with panuveitis had the worst visual prognosis. The systemic diseases associated with a poor visual prognosis were juvenile chronic arthritis and sarcoidosis. Ocular toxoplasmosis was the most frequent cause of unilateral visual loss.Conclusions-Cystoid macular oedema is the most frequent complication of uveitis and its occurrence plays a decisive role in the visual outcome of this disease.