The cortical rhythms of chronic back pain.
The cortical rhythms of chronic back pain.
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DOI：
10.1523/jneurosci.1984-11.2011
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发表时间：
2011-09-28
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影响因子：
--
通讯作者：
Apkarian AV
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作者：
Baliki MN;Baria AT;Apkarian AV
慢性疼痛是适应不良的，它通过改变大脑各区域间信息的流动和整合来影响大脑功能和行为。在此，我们使用功率谱分析来研究慢性疼痛的存在对人类大脑振荡活动的影响。我们在静息态功能磁共振成像期间，检测慢性背痛（CBP）患者（n = 15）与健康对照组（n = 15）相比，不同频率下血氧水平依赖（BOLD）波动的变化。健康受试者表现出一种特定的、依赖频段的大规模神经组织，而患者则表现出高频BOLD振荡（0.12 - 0.20 Hz）增加，主要局限于内侧前额叶皮质（mPFC）和部分默认模式网络（DMN）。在患者中，相关分析将mPFC异常的BOLD高频动态与疼痛信号传导/调节脑区的功能连接改变相关联，从而将BOLD频率变化与功能联系起来。我们还发现，在疼痛评级任务期间，mPFC内频率波动的增加与患者自发疼痛的变化在时间上是同步的。这些观察结果为慢性背痛的性质提供了新的见解，确定了它是如何干扰静息态大脑的，并将高频BOLD振荡与感知联系起来。
Chronic pain is maladaptive and influences brain function and behavior by altering the flow and integration of information across brain regions. Here we use a power spectral analysis to investigate impact of presence of chronic pain on brain oscillatory activity in humans. We examine changes in BOLD fluctuations, across different frequencies, in chronic back pain (CBP) patients (n=15) as compared to healthy controls (n=15) during resting state fMRI. While healthy subjects exhibited a specific, frequency band dependent, large-scale neural organization, patients showed increased high frequency BOLD oscillations (0.12–0.20 Hz) circumscribed mainly to medial prefrontal cortex (mPFC) and parts of the default-mode network (DMN). In the patients a correlation analysis related the mPFC aberrant BOLD high frequency dynamics to altered functional connectivity to pain signaling/modulating brain regions, thus linking BOLD frequency changes to function. We also found that increased frequency fluctuations within the mPFC were temporally synchronous with spontaneous pain changes in patients during a pain-rating task. These observations provide novel insights about the nature of CBP, identifying how it disturbs the resting brain, and link high frequency BOLD oscillations to perception.