Cognitive performance of children prenatally exposed to "safe" levels of methylmercury
Cognitive performance of children prenatally exposed to "safe" levels of methylmercury
复制标题
DOI：
10.1006/enrs.1997.3804
复制
发表时间：
1998-05-01
影响因子：
8.3
通讯作者：
Debes, F
中科院分区：
文献类型：
--
作者：
Grandjean, P;Weihe, P;Debes, F
在法罗群岛 1022 名连续单胎出生的队列中，我们根据孕妇头发汞浓度评估了产前甲基汞暴露情况。大约 7 岁时，917 名儿童接受了详细的神经行为检查。只要孕妇头发中的汞浓度保持在 10-20 μg/g（50-100 nmol/l）以下，就认为发生的风险很小。因此，将母亲头发汞浓度为 10-20 lambda g/g 的 112 名儿童病例组与暴露量低于 3 μg/g 的儿童进行匹配，使用年龄、性别、检查时间和母亲在 Raven 渐进矩阵中的得分作为匹配标准。在可能影响该社区神经行为表现的其他因素方面，两组几乎相同。在六项神经心理学测试指标上，与对照组相比，病例组表现出轻微的下降，特别是在运动功能、语言和记忆领域。因此，在目前认为安全的产前甲基汞暴露水平下，似乎可以检测到对大脑功能的微妙影响。 (C) 1998 年学术出版社。
Within a cohort of 1022 consecutive singleton births in the Faroe Islands, we assessed prenatal methylmercury exposure from the maternal hair mercury concentration. At approximately 7 years of age, 917 of the children underwent detailed neurobehavioral examination. Little risk is thought to occur as long as the hair mercury concentration in pregnant women is kept below 10-20 mu g/g (50-100 nmol/l). A case group of 112 children whose mothers had a hair mercury concentration of 10-20 lambda g/g was therefore matched to children with exposure below 3 mu g/g, using age, sex, time of examination, and the mother's score on Raven's Progressive Matrices as matching criteria. The two groups were almost identical with regard to other factors that might affect neurobehavioral performance in this community. On six neuropsychological test measures, the case group showed mild decrements, relative to controls, especially in the domains of motor function, language, and memory. Subtle effects on brain function therefore seem to be detectable at prenatal methylmercury exposure levels currently considered to be safe. (C) 1998 Academic Press.