Graphene oxide-driven interfacial coupling in laser 3D printed PEEK/PVA scaffolds for bone regeneration
Graphene oxide-driven interfacial coupling in laser 3D printed PEEK/PVA scaffolds for bone regeneration
复制标题
用于骨再生的激光 3D 打印 PEEK/PVA 支架中氧化石墨烯驱动的界面耦合
DOI：
10.1080/17452759.2020.1719457
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发表时间：
2020-02-12
影响因子：
10.6
通讯作者：
Shuai, Cijun
中科院分区：
文献类型：
--
作者：
Feng, Pei;Jia, Jiye;Shuai, Cijun
将聚醚醚酮（PEEK）与聚乙烯醇（PVA）共混，有望获得兼具PEEK优良生物力学性能和PVA显著可降解性的复合支架。然而，非极性PEEK和极性PVA之间的弱界面结合将导致较差的机械性能。在这项研究中，由于其独特的两亲性，氧化石墨烯（GO）被用来增强PEEK/PVA支架中的PEEK和PVA之间的界面结合，通过激光3D打印制造。一方面，GO的大π共轭结构与PEEK中的苯环形成强π-π相互作用。另一方面，GO的含氧基团与PVA的羟基形成强氢键。结果表明，PEEK/PVA界面自由能从37.4 mJ/m（2）降低到29.6 mJ/m（2），PVA相在PEEK基体中变得更加细小均匀，界面结合得到增强。相应地，对于1%的GO负载，PEEK/PVA支架的强度和模量分别增加了97.16%和147.06%。该支架具有良好的亲水性和可降解性，在体外能促进细胞贴壁增殖，在体内能促进成骨分化和骨再生。
Blending Polyetheretherketone (PEEK) with Polyvinyl alcohol (PVA) is promising to obtain a composite scaffold combining the excellent biomechanical properties of PEEK and the remarkable degradability of PVA. However, the weak interfacial bonding between nonpolar PEEK and polar PVA would result in poor mechanical properties. In this study, owing to its unique amphiphilic properties, graphene oxide (GO) was employed to enhance the interfacial bonding between PEEK and PVA in PEEK/PVA scaffolds that were fabricated by laser 3D printing. On the one hand, the large pi-conjugated structure of GO formed strong pi-pi interactions with the benzene rings in PEEK. On the other hand, the oxygen-containing groups of GO formed strong hydrogen bonds with the hydroxyl groups of PVA. As a result, the interfacial free energy between PEEK and PVA decreased from 37.4 to 29.6 mJ/m(2) according to the harmonic-mean rule, and the PVA phase in PEEK matrix became much fine and uniform, indicating a reinforced interfacial bonding. Correspondingly, the strength and modulus of PEEK/PVA scaffolds increased by 97.16% and 147.06%, respectively, for a GO loading of 1%. Furthermore, the scaffolds exhibited good hydrophilicity and degradability, and promoted cell attachment and proliferation in vitro and osteogenic differentiation and bone regeneration in vivo.