Roles of microRNAs and RNA-Binding Proteins in the Regulation of Colorectal Cancer Stem Cells.
Roles of microRNAs and RNA-Binding Proteins in the Regulation of Colorectal Cancer Stem Cells.
复制标题
DOI：
10.3390/cancers9100143
复制
发表时间：
2017-10-24
期刊：
影响因子：
5.2
通讯作者：
Suzuki A
中科院分区：
文献类型：
--
作者：
Mukohyama J;Shimono Y;Minami H;Kakeji Y;Suzuki A
结直肠癌干细胞（Colorectal Cancer Stem Cells，CSC）是人类结直肠癌发生、发展和转移的重要细胞，其特征在于表达细胞表面标志物，如CD44、CD133、CD166和LGR 5。微小RNA（microRNAs，miRNAs）在肿瘤干细胞和非致瘤性肿瘤细胞中差异表达，在维持和调节肿瘤干细胞特性中发挥重要作用。RNA结合蛋白（RNA binding proteins，RBP）是近年来发现的一类重要的RNA加工调控因子，参与了RNA的剪接、定位、稳定和翻译等过程，并可调控多种干细胞。本文就miRNA和RBPs在大肠癌干细胞调控中的作用进行综述。了解人类结直肠CSC的表观遗传调控将有助于开发结直肠癌的生物标志物，并确定CSC靶向治疗的靶点。
Colorectal cancer stem cells (CSCs) are responsible for the initiation, progression and metastasis of human colorectal cancers, and have been characterized by the expression of cell surface markers, such as CD44, CD133, CD166 and LGR5. MicroRNAs (miRNAs) are differentially expressed between CSCs and non-tumorigenic cancer cells, and play important roles in the maintenance and regulation of stem cell properties of CSCs. RNA binding proteins (RBPs) are emerging epigenetic regulators of various RNA processing events, such as splicing, localization, stabilization and translation, and can regulate various types of stem cells. In this review, we summarize current evidences on the roles of miRNA and RBPs in the regulation of colorectal CSCs. Understanding the epigenetic regulation of human colorectal CSCs will help to develop biomarkers for colorectal cancers and to identify targets for CSC-targeting therapies.
登录
查看更多内容
DOI：
10.1002/stem.2594
发表时间：
2017-04
期刊：
Stem cells (Dayton, Ohio)
影响因子：
--
作者：
Cochrane A;Kelaini S;Tsifaki M;Bojdo J;Vilà-González M;Drehmer D;Caines R;Magee C;Eleftheriadou M;Hu Y;Grieve D;Stitt AW;Zeng L;Xu Q;Margariti A
通讯作者：
Margariti A
影响因子：
16.6
作者：
Cantini L;Isella C;Petti C;Picco G;Chiola S;Ficarra E;Caselle M;Medico E
通讯作者：
Medico E
影响因子：
2.6
作者：
Bobryshev, Y. V.;Freeman, A. K.;Lord, R. V. N.
通讯作者：
Lord, R. V. N.
MYB-QKI重排在血管中心神经胶质瘤中通过三方机制驱动肿瘤性。
影响因子：
30.8
作者：
Bandopadhayay P;Ramkissoon LA;Jain P;Bergthold G;Wala J;Zeid R;Schumacher SE;Urbanski L;O'Rourke R;Gibson WJ;Pelton K;Ramkissoon SH;Han HJ;Zhu Y;Choudhari N;Silva A;Boucher K;Henn RE;Kang YJ;Knoff D;Paolella BR;Gladden-Young A;Varlet P;Pages M;Horowitz PM;Federation A;Malkin H;Tracy AA;Seepo S;Ducar M;Van Hummelen P;Santi M;Buccoliero AM;Scagnet M;Bowers DC;Giannini C;Puget S;Hawkins C;Tabori U;Klekner A;Bognar L;Burger PC;Eberhart C;Rodriguez FJ;Hill DA;Mueller S;Haas-Kogan DA;Phillips JJ;Santagata S;Stiles CD;Bradner JE;Jabado N;Goren A;Grill J;Ligon AH;Goumnerova L;Waanders AJ;Storm PB;Kieran MW;Ligon KL;Beroukhim R;Resnick AC
通讯作者：
Resnick AC
影响因子：
11.2
作者：
Collins, AT;Berry, PA;Maitland, NJ
通讯作者：
Maitland, NJ