UCSF Small Molecule Discovery Center: Innovation, Collaboration and Chemical Biology in the Bay Area
UCSF Small Molecule Discovery Center: Innovation, Collaboration and Chemical Biology in the Bay Area
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DOI：
10.2174/1386207317666140323133841
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发表时间：
2014-05-01
影响因子：
1.8
通讯作者：
Renslo, Adam R.
中科院分区：
文献类型：
--
作者：
Arkin, Michelle R.;Ang, Kenny K. H.;Renslo, Adam R.
加州大学旧金山分校弗朗西斯科的小分子发现中心（SMDC）与科学界合作，解决化学生物学和药物发现方面的挑战性问题。SMDC包括高通量筛选设施，药物化学和研究实验室，专注于生物化学和靶向药物输送的基本问题。在这里，我们概述了我们的HTS计划，并提供了通过SMDC合作开发的化学工具的例子。我们有一个积极的研究计划，在开发定量细胞为基础的屏幕为原代细胞和整个生物体;在这里，我们描述了整个生物体屏幕，以寻找药物对寄生虫，导致被忽视的热带疾病。我们也非常感兴趣的目标为基础的方法，所谓的“undruggable”，蛋白质类和片段为基础的铅发现。这种专业知识导致了几次制药合作;此外，SMDC与初创公司合作，使他们的早期研究成为可能。SMDC位于旧金山弗朗西斯科以生物技术为重点的使命湾附近，是加州大学旧金山分校创新小分子发现研究的中心。
The Small Molecule Discovery Center (SMDC) at the University of California, San Francisco, works collaboratively with the scientific community to solve challenging problems in chemical biology and drug discovery. The SMDC includes a high throughput screening facility, medicinal chemistry, and research labs focused on fundamental problems in biochemistry and targeted drug delivery. Here, we outline our HTS program and provide examples of chemical tools developed through SMDC collaborations. We have an active research program in developing quantitative cell-based screens for primary cells and whole organisms; here, we describe whole-organism screens to find drugs against parasites that cause neglected tropical diseases. We are also very interested in target-based approaches for so-called "undruggable", protein classes and fragment-based lead discovery. This expertise has led to several pharmaceutical collaborations; additionally, the SMDC works with start-up companies to enable their early-stage research. The SMDC, located in the biotech-focused Mission Bay neighborhood in San Francisco, is a hub for innovative small-molecule discovery research at UCSF.