Large granular lymphocyte leukemia. A heterogeneous lymphocytic leukemia in F344 rats.
Large granular lymphocyte leukemia. A heterogeneous lymphocytic leukemia in F344 rats.
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大颗粒淋巴细胞白血病。
DOI：
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发表时间：
1983
影响因子：
6
通讯作者：
Craig W. Reynolds
中科院分区：
文献类型：
--
作者：
J. Ward;Craig W. Reynolds
The morphology, histochemistry, cell surface antigens, and natural killer cell (NK) activity of 10 primary and 10 transplantable large granular lymphocyte (LGL) leukemias of aging F344 rats were studied. The LGL leukemia is the major cause of death of aging F344 rats. Morphologically, the LGL leukemias were composed of cells with either pleomorphic nuclei with many intracytoplasmic granules or round nuclei with few intracytoplasmic granules. The granules appeared to be lysosomes containing beta-glucuronidase and acid phosphatase and ultrastructurally developed in association with vesicles in the Golgi apparatus. Splenic natural killer cell activity against YAC-1 cells varied from case to case, and it appeared to be associated with LGL leukemia cells. Some transplantable leukemias had stable NK activity. Fluorescence-activated cell sorter (FACS) analysis of surface antigens revealed the LGL leukemias to be heterogeneous, and there was no correlation between cytotoxic activity and cell surface antigens. Although the morphologic features of cells in LGL leukemias resemble those of normal rat LGLs, differences in cytotoxic activity and surface antigens suggest that LGL tumors represent a heterogeneous group of leukemias which may serve as a model for the study of origin and lineage of normal LGL and NK cells.
辐射对大鼠肿瘤发生率的矛盾效应：对放射治疗的影响。
影响因子：
11.2
作者：
Hellman,S;Moloney,WC;Meissner,WA
通讯作者：
Meissner,WA