Changing pattern of hepatitis C virus spread in rural areas of Egypt
Changing pattern of hepatitis C virus spread in rural areas of Egypt
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DOI：
10.1016/j.jhep.2005.03.021
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发表时间：
2005-09-01
影响因子：
25.7
通讯作者：
Fontanet, A
中科院分区：
文献类型：
--
作者：
Arafa, N;El Hoseiny, M;Fontanet, A
背景/目标：为了确定在埃及尼罗河三角洲的HCV传播模式。方法：在尼罗河三角洲的村庄居民被邀请参加HCV感染的队列研究。使用广义估计方程模型在队列摄入时确定既往或当前感染的风险因素。所有独立的危险因素计算归因分数。结果：丙型肝炎病毒抗体的患病率从2.7%，在那些< 20岁的40-54岁的男性超过40%。40-54岁年龄组的HCV流行率高峰对应于20世纪60 -70年代通过血吸虫病静脉注射治疗感染的儿童队列的老龄化（占今天在成人中观察到的所有HCV感染的12.4%）。在这一最初的创始事件之后，HCV流行通过医源性因素在社区中传播，特别是注射（占成人总体归因分数的37.9%）。然而，在儿童中，没有医源性因素与感染的风险增加，这表明在HCV spreads.Conclusions的模式的变化：虽然成人中的HCV感染可归因于医源性因素，特别是注射，在儿童中的感染不能被解释为类似的传播途径。(c)2005年欧洲肝脏研究协会。Elsevier B. V.出版，保留所有权利。
Background/Aims: To identify patterns of HCV spread in the Nile Delta of Egypt.Methods: Residents in a Nile Delta village were invited to participate in a cohort study of HCV infection. Risk factors for past or current infection were identified at cohort intake using generalized estimated equations models. Attributable fractions were calculated for all independent risk factors.Results: The prevalence of HCV antibodies increased from 2.7% in those < 20 years of age to more than 40% in males aged 40-54 years. The peak in HCV prevalence in the 40-54 year age group corresponds to the aging of the cohort of children infected through schistosomiasis intravenous treatments in the 1960s-70 s (accounting for 12.4% of all HCV infections observed today among adults). Following this initial founding event, the HCV epidemic has spread in the community through iatrogenic factors, and particularly injections (37.9% of the overall attributable fraction in adults). In children, however, no iatrogenic factors were associated with increased risk of infection, suggesting a change in the pattern of HCV spread.Conclusions: While HCV infections in adults could be attributed to iatrogenic factors, and particularly injections, infections in children could not be explained by similar routes of transmission. (c) 2005 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.