Correlative Electrophysiological and Anatomical Studies Concerning the Site of Origin of Escape Rhythm during Complete Atrioventricular Block in the Dog
Correlative Electrophysiological and Anatomical Studies Concerning the Site of Origin of Escape Rhythm during Complete Atrioventricular Block in the Dog
复制标题
狗完全性房室传导阻滞时逃逸节律起源部位的相关电生理学和解剖学研究
DOI：
10.1161/01.res.45.1.108
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发表时间：
1979
影响因子：
20.1
通讯作者：
And Ferdinand Urthaler
中科院分区：
文献类型：
--
作者：
T. James;J. Isobe;And Ferdinand Urthaler
在8只狗的房室结动脉内选择性灌注毒扁豆碱或新斯的明，造成完全性心脏传导阻滞。每只狗都出现了特征性的逸搏AV交界节律。用阿托品逆转胆碱酯酶麻痹后，在每只狗中通过切开房室结区域产生部分心脏传导阻滞。在这8只犬中的3只犬中，第二个切口放置在稍靠前的位置，产生完全房室传导阻滞，随后出现与产生的房室传导阻滞相似的逸搏房室交界性心律。用连续切片对这三只犬的心脏进行组织学检查，以确定切口的确切位置及其与房室结和希氏束的关系。在每只狗中，产生完全性心脏传导阻滞的切口直接穿过房室结与希氏束的交界处。在这个区域，以前的研究已经证明了大量的P细胞，这被认为是正常心脏自律性的起源部位。在这三个心脏中，每一个都有大量的连续的P细胞--希氏束位于产生心脏传导阻滞的切口的远端。这些研究结果的意义进行了讨论相对于乙酰胆碱的AV交界处内的行动轨迹，AV交界处的节奏的起源的网站，以及心脏传导阻滞的实验和治疗生产的某些方面。《矿石研究》45：108-119，1979年
Complete heart block was produced in eight dogs by the selective perfusion of physostdgmine or neostigmine into the atrioventricular (AV) node artery. A characteristic escape AV junctional rhythm emerged in each dog. After reversal of the cholinesterase paralysis with atropine, in each dog partial heart block was produced by an incision into the AV nodal region. In three of these eight dogs, a second incision placed slightly more anteriorly produced complete AV block which was followed by the emergence of an escape AV junctional rhythm similar to the one produced pharmacologically. Hearts of these three dogs were examined hiatologically with serial sections to determine the exact location of the incisions and their relationship to the AV node and His bundle. In each dog the incision that produced complete heart block passed directly through the junction of AV node with His bundle. In this region previous studies had demonstrated numerous P cells, which are thought to be the site of origin of normal cardiac automaticity. In each of the three hearts there were abundant P cells in continuity-with the His bundle distal to the cut producing heart block. Significance of these findings is discussed relative to the locus of action of acetylcholine within the AV junction, the site of origin of AV junctional rhythm, and some aspects of the experimental and therapeutic production of heart block. Ore Res 45:108-119, 1979