Prolonged persistence of SARS-CoV-2 in the upper respiratory tract of asymptomatic infected individuals
Prolonged persistence of SARS-CoV-2 in the upper respiratory tract of asymptomatic infected individuals
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DOI：
10.1093/qjmed/hcaa212
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发表时间：
2020-08-01
影响因子：
13.3
通讯作者：
Misra, S.
中科院分区：
文献类型：
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作者：
Saurabh, S.;Kumar, R.;Misra, S.
背景：SARS-CoV-2 在感染者上呼吸道中持续存在的时间具有重要的临床和流行病学意义。目的：我们旨在确定 SARS-CoV-2 在无症状感染者上呼吸道中持续存在的持续时间和危险因素。方法：从 3 月 19 日开始，对印度焦特布尔研究所对 SARS-CoV-2 感染者进行的重复 rRT-PCR（实时逆转录聚合酶链式反应）检测数据进行了分析至 2020 年 5 月 21 日。病毒持续时间是通过基于威布尔、对数正态、对数逻辑、伽马和广义伽马分布的参数回归模型估计的。使用最佳拟合模型分析了与病毒持续时间延长相关的因素。 结果：通过重复 rRT-PCR 检测，确定了 51 名 SARS-CoV-2 感染者，其中 44 名无症状。无症状个体的中位病毒持续时间为 8.87 天（95% CI：7.65-10.27），95% 持续时间为 20.70 天（95% CI：16.08-28.20）。包括有症状和无症状个体在内的总体病毒持续时间中位数为 9.18 天（95% CI：8.04-10.48）。大约四分之一的无症状患者 (10/44) 表现出 SARS-CoV-2 的持续存在时间超过 2 周。年龄
Background: Duration of persistence of SARS-CoV-2 in the upper respiratory tract of infected individuals has important clinical and epidemiological implications.Aim: We aimed to establish the duration and risk factors for persistence of SARS-CoV-2 in the upper respiratory tract of asymptomatic infected individuals.Methods: Data of repeat rRT-PCR (real-time reverse transcription-polymerase chain reaction) test done for SARS-CoV-2 infected individuals at our institute at Jodhpur, India were analysed from 19 March to 21 May 2020. Duration of virus persistence was estimated with parametric regression models based on weibull, log-normal, log-logistic, gamma and generalized gamma distributions. Factors associated with prolonged viral persistence were analysed with the best-fitting model.Results: Fifty-one SARS-CoV-2 infected individuals with repeat rRT-PCR test were identified with 44 asymptomatics. The asymptomatic individuals had median virus persistence duration of 8.87 days (95% CI: 7.65-10.27) and 95 percentile duration of 20.70 days (95% CI: 16.08-28.20). The overall median virus persistence including both symptomatic and asymptomatic individuals was found to be 9.18 days (95% CI: 8.04-10.48). Around one-fourth asymptomatics (10/44) demonstrated SARS-CoV-2 persistence beyond 2 weeks. Age