Bronchial washing levels of vascular endothelial growth factor receptor-2 (VEGFR2) correlate with overall survival in NSCLC patients
Bronchial washing levels of vascular endothelial growth factor receptor-2 (VEGFR2) correlate with overall survival in NSCLC patients
复制标题
DOI：
10.1016/j.canlet.2011.02.018
复制
发表时间：
2011-05-28
期刊：
影响因子：
9.7
通讯作者：
Syrigos, Kostas N.
中科院分区：
文献类型：
--
作者：
Charpidou, Andriani;Gkiozos, Ioannis;Syrigos, Kostas N.
本研究的目的是确定NSCLC患者血清和支气管冲洗样本中治疗前VEGF、VEGFR 1和VEGFR 2水平，以检查其与生存率的相关性。入组了40例经组织学证实的NSCLC患者。结果表明，循环VEGF与T分类相关，血清和洗涤液中VEGF/VEGFR 2的比值也是如此。在较低的血清和洗涤VEGF浓度下观察到最佳化疗反应。洗涤中较高的VEGF水平与较差的总生存期和无进展生存期相关。在洗涤中VEGF/VEGFR 2比率的高值下的结果类似。多变量分析显示，血清和洗涤液中的VEGFR 2水平是总生存期的独立标志物。总之，洗涤VEGFR 2水平与总生存期相关，而血清和洗涤VEGF水平可预测化疗反应。这些可以帮助识别受益于积极治疗方法的NSCLC患者。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
The aim of this study was to define pre-treatment VEGF, VEGFR1 and VEGFR2 levels in serum and bronchial washing samples of NSCLC patients in order to examine their correlation to survival. Forty patients with histologically confirmed NSCLC were enrolled. The results indicated that circulating VEGF was correlated to T-classification, as were the ratios of VEGF/VEGFR2 in serum and washing. Best chemotherapy response was observed at lower serum and washing VEGF concentrations. Higher VEGF levels in washing were associated with worse overall survival and progression-free survival. Similar were the results at high values of VEGF/VEGFR2 ratio in washing. Multivariate analysis revealed VEGFR2 levels in serum and washing as independent markers for overall survival. In conclusion, washing VEGFR2 levels are correlated to overall survival, whereas serum and washing VEGF levels are predictive of chemotherapy response. These could help recognize NSCLC patients who benefit from an aggressive therapeutic approach. (C) 2011 Elsevier Ireland Ltd. All rights reserved.