Salvinorin A: from natural product to human therapeutics.
Salvinorin A: from natural product to human therapeutics.
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DOI：
10.1124/mi.6.5.7
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发表时间：
2006-10
影响因子：
--
通讯作者：
T. Vortherms;B. Roth
中科院分区：
文献类型：
--
作者：
T. Vortherms;B. Roth
迷幻植物鼠尾草(即“魔力薄荷”)是圣人家族的成员，曾被马扎特克人用于占卜和萨满教。在过去十年左右的时间里，Divinorum越来越多地被用于娱乐用途。新樱桃烷二萜萨尔维诺菌素A是Divinorum的活性成分，近年来，Kappa阿片受体(KOR)已被确定为其分子靶标。KOR作为Salvinorin A的分子靶点的发现为许多精神和非精神疾病的药物发现和药物开发打开了许多机会。
The hallucinogenic plant Salvia divinorum (i.e., "magic mint") is a member of the Sage family that has been used for divination and shamanism by the Mazatecs. Over the past decade or so, S. divinorum has been increasingly used recreationally. The neoclerodane diterpene salvinorin A is the active component of S. divinorum, and recently, the kappa opioid receptor (KOR) has been identified, in vitro and in vivo, as its molecular target. The discovery of KOR as the molecular target of salvinorin A has opened up many opportunities for drug discovery and drug development for a number of psychiatric and non-psychiatric disorders.