Characterization of a highly cross-linked ultrahigh molecular-weight polyethylene in clinical use in total hip arthroplasty
Characterization of a highly cross-linked ultrahigh molecular-weight polyethylene in clinical use in total hip arthroplasty
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DOI：
10.1016/j.arth.2007.06.006
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发表时间：
2008-08-01
影响因子：
3.5
通讯作者：
Yao, Jian Q.
中科院分区：
文献类型：
--
作者：
Laurent, Michel P.;Johnson, Todd S.;Yao, Jian Q.
本文报告了一种市售的广泛交联超高分子量聚乙烯（HXPE），其通过对模塑GUR 1050超高分子量聚乙烯（UHMWPE）进行100 +/- 10 kGy的电子束辐射，然后进行熔融退火和气体等离子体灭菌而生产。与采用37 kGy伽马辐照灭菌的当代传统模塑GUR 1050 UHMWPE相比，HXPE材料具有增强的磨损性能，没有可检测到的自由基，并且抗氧化和氧化相关材料性能变化。在存在骨水泥或氧化铝颗粒的情况下，HXPE的相对磨损改善得以维持。与传统UHMWPE相比，HXPE在所有尺寸范围内产生的磨损颗粒减少90%以上，平均尺寸颗粒在统计学上显著（P <0.0001）更小。
This article reports on a commercially available extensively cross-linked ultrahigh molecular-weight polyethylene (HXPE) produced by subjecting molded GUR 1050 ultrahigh molecular-weight polyethylene (UHMWPE) to 100 +/- 10 kGy of electron beam radiation followed by melt annealing and sterilization by gas plasma. When compared to contemporary conventional molded GUR 1050 UHMWPE sterilized by 37 kGy of gamma radiation, the HXPE material has enhanced wear properties, has no detectable free radicals, and is resistant to oxidation and oxidative-related material property changes. The relative wear improvement of the HXPE is maintained in the presence of bone cement or alumina particles. The HXPE produced greater than 90% fewer wear particles in all size ranges and statistically significantly (P < .0001) smaller average-size particles than did the conventional UHMWPE.