Clinical Consequences of Diet-Induced Dysbiosis
Clinical Consequences of Diet-Induced Dysbiosis
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DOI：
10.1159/000354902
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发表时间：
2013-01-01
影响因子：
3.9
通讯作者：
Gibson, Deanna L.
中科院分区：
文献类型：
--
作者：
Chan, Yee Kwan;Estaki, Mehrbod;Gibson, Deanna L.
各种疾病状态与肠道中保护性和致病性细菌的失衡有关，称为生态失调。目前的证据表明，饮食因素会影响肠道中的微生物生态系统。考虑到微生物对局部和全身免疫的广泛影响，肠道微生物群群落结构的变化并非没有后果。本综述的目的是深入了解肠道微生物群在疾病发展中的重要性以及临床环境中可能的治疗干预措施。我们介绍了饮食，微生物和肠道上皮之间复杂的三方关系。其次是总结饮食引起的生态失调作为胃肠道疾病如炎症性肠病、肠易激综合征和结直肠癌以及全身性疾病如肥胖、糖尿病、动脉粥样硬化和非酒精性脂肪肝的发展的促成因素的临床证据。最后，目前的饮食和微生物干预，以促进健康的微生物概况将进行审查。(C)2013 S. Karger AG，巴塞尔
Various disease states are associated with an imbalance of protective and pathogenic bacteria in the gut, termed dysbiosis. Current evidence reveals that dietary factors affect the microbial ecosystem in the gut. Changes to community structure of the intestinal microbiota are not without consequence considering the wide effects that the microbes have on both local and systemic immunity. The goal of this review is to give insight into the importance of gut microbiota in disease development and the possible therapeutic interventions in clinical settings. We introduce the complex tripartite relationship between diet, microbes and the gut epithelium. This is followed by a summary of clinical evidence of dietinduced dysbiosis as a contributing factor in the development of gastrointestinal diseases like inflammatory bowel disease, irritable bowel syndrome and colorectal cancer, as well as systemic diseases like obesity, diabetes, atherosclerosis and nonalcoholic fatty liver disease. Finally, the current dietary and microbial interventions to promote a healthy microbial profile will be reviewed. (C) 2013 S. Karger AG, Basel