Reduced allorecognition of adenovirus-2 infected cells.
Reduced allorecognition of adenovirus-2 infected cells.
复制标题
腺病毒 2 感染细胞的同种异体识别减少。
DOI：
10.4049/jimmunol.138.11.3960
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发表时间：
1987
影响因子：
4.4
通讯作者：
P. A. Peterson
中科院分区：
文献类型：
--
作者：
M. Andersson;A. McMichael;P. A. Peterson
腺病毒 2 的早期区域 3 编码膜糖蛋白 E19。该蛋白特异性结合多种物种的 I 类移植抗原。伴随着这种相互作用，新合成的 I 类重链的细胞内运输被消除。在病毒感染的后期，这会导致 I 类抗原的细胞表面表达显着减少。我们研究了腺病毒 2 感染如何影响同种反应性溶细胞 T 淋巴细胞对靶细胞的识别。我们发现 E19 蛋白诱导的 HLA-B7 细胞表面表达减少导致受感染细胞的裂解大大减少。这些发现支持了我们的假设，即 E19 蛋白已经进化为通过减少 HLA I 类抗原的表达来促进病毒的体内复制。
The early region 3 of adenovirus 2 encodes the membrane glycoprotein E19. This protein specifically binds class I transplantation antigens of a variety of species. Concomitant with this interaction the intracellular transport of newly synthesized class I heavy chains is abrogated. At late stages of the virus infection this leads to a notable decrease in the cell surface expression of class I antigens. We have studied how infection with adenovirus 2 influences target cell recognition by alloreactive cytolytic T lymphocytes. We found that the E19 protein-induced reduction of the HLA-B7 cell surface expression led to a greatly reduced lysis of the infected cells. These findings support our hypothesis that the E19 protein has evolved to facilitate the in vivo replication of the virus by reducing the expression of HLA class I antigens.