Host endomembrane recruitment for plant RNA virus replication.
Host endomembrane recruitment for plant RNA virus replication.
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DOI：
10.1016/j.coviro.2012.10.003
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发表时间：
2012-12
影响因子：
5.9
通讯作者：
Laliberté JF
中科院分区：
文献类型：
--
作者：
Grangeon R;Jiang J;Laliberté JF
有些植物病毒感染导致形成大的核周球状结构。这些结构包含病毒复制复合体和内质网和高尔基体的融合。参与病毒运动的外周运动病毒诱导的囊泡与这些核周结构相关。虽然有大量的文献，涉及鉴定植物病毒蛋白参与膜重塑和囊泡生产在受感染的细胞，有很少的调查报告的影响，感染的早期分泌内膜的整体结构和动力学。最近的研究表明，对于一些病毒，内质网，高尔基体和其他细胞器大量招募到病毒诱导的核周结构。这些结构不是孤立的细胞器，而是动态地连接到未修饰的内膜的主体。它们还与参与病毒细胞内运动的外周运动囊泡有功能联系。在病毒诱导的结构中与内膜募集一致的完整分子事件仍有待阐明，但病毒基因组复制和病毒体组装可能发生在这些结构中。
► Some plant virus infections lead to the formation of large perinuclear globular structures. ► These structures contain viral replication complexes and an amalgamation of endoplasmic reticulum and Golgi bodies. ► Peripheral motile virus-induced vesicles involved in virus movement are linked to these perinuclear structures. Although there is a significant amount of literature that deals with the identification of plant viral proteins involved in membrane remodeling and vesicle production in infected cells, there are very few investigations that report on the impact that infection has on the overall architecture and dynamics of the early secretory endomembranes. Recent investigations have shown that for some viruses the endoplasmic reticulum, Golgi bodies and other organelles are heavily recruited into virus-induced perinuclear structures. These structures are not isolated organelles and are dynamically connected to the bulk of non-modified endomembranes. They also have a functional link with peripheral motile vesicles involved in virus intracellular movement. The full molecular events that consubstantiate with this endomembrane recruitment in virus-induced structures remain to be elucidated but viral genome replication and virion assembly are probably taking place within these structures.
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