Central L-proline attenuates stress-induced dopamine and serotonin metabolism in the chick forebrain
Central L-proline attenuates stress-induced dopamine and serotonin metabolism in the chick forebrain
复制标题
DOI：
10.1016/j.neulet.2009.05.036
复制
发表时间：
2009-08-21
影响因子：
2.5
通讯作者：
Furuse, Mitsuhiro
中科院分区：
文献类型：
--
作者：
Hamasu, Kousuke;Shigemi, Kazutaka;Furuse, Mitsuhiro
用微透析法观察了L-脯氨酸对自由活动雏鸡和限制活动雏鸡新纹状体内侧/高纹状体腹侧单胺释放的影响。30min的处理胁迫导致多巴胺代谢产物胞外高香草酸(HVA)和5-羟基吲哚乙酸(5-HIAA)显著增加。一种5-羟色胺代谢物，在MNH中。在应激状态下，通过微透析探头向MNH灌流L-脯氨酸，可显著降低应激所产生的HVA的平均浓度。应激可使对照组大鼠血浆5-HIAA水平显著升高，而L-脯氨酸灌胃可使其降低。在对照条件下，L-脯氨酸没有显著改变MNH中HVA或5-HIAA的基础浓度。这些结果表明，L-脯氨酸的灌流改变了操作应激所致的MNH中多巴胺和5-羟色胺的代谢。(C)2009爱思唯尔爱尔兰有限公司。保留所有权利。
Using microdialysis, we investigated the effect Of L-proline on monoamine release in the medio-rostral neostriatum/hyperstriatum ventrale (MNH) of freely moving and restricted chicks. A 30 min handling-stress resulted in a significant increase in extracellular homovallinic acid (HVA), a dopamine metabolite, and 5-hydroxyindoleacetic acid (5-HIAA). a serotonin metabolite, in the MNH. L-Proline, perfused through the microdialysis probe into the MNH during the stressed condition, significantly attenuated the average dialysate concentration of HVA produced by handling-stress. Handling-stress resulted in a significant increase in 5-HIAA levels in the control group, which were attenuated by profusion with L-proline. L-Proline did not significantly modify basal concentrations of HVA or 5-HIAA in the MNH during control conditions. These results show that perfusion of L-proline modified the turnover/metabolism of dopamine and serotonin in the MNH caused by handling-stress. (C) 2009 Elsevier Ireland Ltd. All rights reserved.