The Retrovirus Capsid Core.
The Retrovirus Capsid Core.
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逆转录病毒衣壳核心。
DOI：
10.1007/978-981-10-8456-0_8
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发表时间：
2018
影响因子：
--
通讯作者：
Mansky,LouisM
中科院分区：
文献类型：
--
作者：
Zhang,Wei;Mendonça,LuizaM;Mansky,LouisM
逆转录病毒衣壳核心是一种亚稳定结构，在病毒感染的早期阶段膜融合后解体。在逆转录过程中，核心是完整的，并可渗透到必要的核苷酸，但它经历了分解，以进入核和基因组整合。增加或降低衣壳核心的稳定性对病毒感染性有很大的负面影响，这使核心成为有吸引力的抗病毒靶点。逆转录病毒衣壳核心还会遇到各种病毒和生物体特有的宿主细胞因子，这些因子促进或限制病毒复制。这篇综述描述了衣壳核心形成和稳定的基本结构要素。强调衣壳核心的物理和化学性质，这些性质对于其在逆转录中的功能作用以及与宿主细胞因子的相互作用至关重要，以强调当前的研究领域。
The retrovirus capsid core is a metastable structure that disassembles during the early phase of viral infection after membrane fusion. The core is intact and permeable to essential nucleotides during reverse transcription, but it undergoes disassembly for nuclear entry and genome integration. Increasing or decreasing the stability of the capsid core has a substantial negative impact on virus infectivity, which makes the core an attractive anti-viral target. The retrovirus capsid core also encounters a variety of virus- and organism-specific host cellular factors that promote or restrict viral replication. This review describes the structural elements fundamental to the formation and stability of the capsid core. The physical and chemical properties of the capsid core that are critical to its functional role in reverse transcription and interaction with host cellular factors are highlighted to emphasize areas of current research.