Semen parameters and hormonal profile in obese fertile and infertile males
Semen parameters and hormonal profile in obese fertile and infertile males
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DOI：
10.1016/j.fertnstert.2009.03.085
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发表时间：
2010-07-01
影响因子：
6.7
通讯作者：
Mostafa, Taymour
中科院分区：
文献类型：
--
作者：
Hofny, Eman R. M.;Ali, Mohamed E.;Mostafa, Taymour
目的：研究肥胖生育和少精子症患者精液参数、促性腺激素、性激素和血清瘦素水平的变化。设计：前瞻性研究。地点：大学医院。患者：S，肥胖生育男性42例，肥胖少精子症男性80例(体重指数和GT；干预(S)：体重指数计算、精液分析、血清FSH、LH、T、E-2、PRL、瘦素测定。主要观察指标(S)：精液和激素谱。结果(S)：肥胖少精子症患者的平均体重指数、血清FSH、LH、E-2、PRL和瘦素水平显著高于肥胖生育对照组。BMI与精子形态异常、黄体生成素、血清瘦素呈显著正相关，与精子密度、精子活力、血清T呈显著负相关。血清瘦素与患者年龄、精子形态异常、血清FSH、LH、PRL呈显著正相关，与精子密度、精子活力、血清T呈显著负相关。结论：血清瘦素参与了肥胖与男性不育的关系。(Fertil Steril(R)2010；94：581-4.(C)2010年由美国生殖医学学会公布。)
Objective: To study the changes in semen parameters, gonadotropic and sex hormones, and serum leptin in obese fertile and infertile oligozoospermic men.Design: Prospective.Setting: University hospital.Patient(s): Forty-two obese fertile and 80 obese infertile oligozoospermic men (body mass index [BMI] > 30).Intervention(s): The BMI calculation, semen analysis, and serum FSH, LH, T, E-2, PRL, and leptin estimation.Main Outcome Measure(s): Semen and hormonal profiles.Result(s): Obese oligozoospermic patients had significant increase in mean BMI, serum FSH, LH, E-2, PRL, and leptin compared with obese fertile controls. The BMI had significant positive correlation with abnormal sperm morphology, LH, serum leptin and significant negative correlation with sperm concentration, sperm motility, serum T. Serum leptin demonstrated significant positive correlation with patients' age, abnormal sperm morphology, serum FSH, LH, PRL and significant negative correlation with sperm concentration, sperm motility, and serum T.Conclusion(s): Serum leptin mediates a link between obesity and male infertility. (Fertil Steril (R) 2010;94:581-4. (C) 2010 by American Society for Reproductive Medicine.)