Smaller left hemisphere planum temporale in adults with autistic disorder
Smaller left hemisphere planum temporale in adults with autistic disorder
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DOI：
10.1016/s0304-3940(02)00521-9
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发表时间：
2002-08-16
影响因子：
2.5
通讯作者：
Rogers, SJ
中科院分区：
文献类型：
--
作者：
Rojas, DC;Bawn, SD;Rogers, SJ
颞平面的结构经常在与相关的沟通问题，特别是在大脑中的听觉和语言处理区域的障碍扰乱。我们假设自闭症患者左半球颞平面（一种与语言相关的大脑结构）的体积会减少。我们进行了磁共振成像扫描的15名成人自闭症患者和15名对照组，并测量了在颞平面和Heschl的回（HG）在两个半球的灰质体积。孤独症组左半球颞平面体积减小（P < 0.003）。两组间未观察到HG体积差异。在自闭症组左半球看到的体积减少可能表明自闭症的早期神经发育障碍影响语言发育。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
The structure of the planum temporale is often disturbed in disorders with associated communication problems, particularly in auditory and language processing areas in the brain. We hypothesized that people with autism would have reduced left hemisphere volumes in the planum temporale, a language related brain structure. We performed magnetic resonance imaging scans of 15 adults with autistic disorder and 15 comparison subjects, and measured the volume of gray matter in the planum temporale and Heschl's gyrus (HG) in both hemispheres. Planum temporale volume reduced in the left hemisphere of the autism group (P < 0.003). No differences in HG volumes were observed between the two groups. The volume reduction seen in the left hemisphere of the autism group may suggest an early neurodevelopmental disturbance in autism that impacts language development. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.