Shp1 function in myeloid cells
Shp1 function in myeloid cells
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DOI：
10.1189/jlb.2mr0317-105r
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发表时间：
2017-09-01
影响因子：
5.5
通讯作者：
Lowell, Clifford A.
中科院分区：
文献类型：
--
作者：
Abram, Clare L.;Lowell, Clifford A.
1975年首次描述了作为免疫系统失调的结果的全身炎症和自身免疫的模型。该表型后来被归因于细胞质酪氨酸磷酸酶Shp1的突变。这种磷酸酶在整个造血系统中广泛表达，并已被证明会影响多种细胞信号传导途径。确定哪些细胞类型有助于由全球Shp1丢失或突变引起的表型的不同方面，以及这些细胞类型中的哪些途径受Shp1调节，对于进一步了解免疫系统调节非常重要。在这篇综述中，我们重点关注Shp1在骨髓细胞中的作用，以及它的失调如何影响免疫功能，从而影响人类疾病。
The motheaten mouse was first described in 1975 as a model of systemic inflammation and autoimmunity, as a result of immune system dysregulation. The phenotype was later ascribed to mutations in the cytoplasmic tyrosine phosphatase Shp1. This phosphatase is expressed widely throughout the hematopoietic system and has been shown to impact a multitude of cell signaling pathways. The determination of which cell types contribute to the different aspects of the phenotype caused by global Shp1 loss or mutation and which pathways within these cell types are regulated by Shp1 is important to further our understanding of immune system regulation. In this review, we focus on the role of Shp1 in myeloid cells and how its dysregulation affects immune function, which can impact human disease.