The meaning of intragenomic conflict
The meaning of intragenomic conflict
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DOI：
10.1038/s41559-017-0354-9
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发表时间：
2017-12-01
影响因子：
16.8
通讯作者：
Ubeda, Francisco
中科院分区：
文献类型：
--
作者：
Gardner, Andy;Ubeda, Francisco
近年来，人们对基因的兴趣激增，这些基因对自身有益，对同一基因组中的其他基因有害。人们日益认识到，这种基因组内冲突是适应不良和疾病的根源。然而，由于对基因组内冲突的真正含义缺乏清晰的理解，以及对其基本驱动因素的相关模糊，进展受到了阻碍。在这里，我们发展了基因组内冲突的一般理论，其中基因被视为包容性适应度最大化的代理人，当它们的包容性适应度利益不一致时，它们就会发生冲突。这就产生了一种将所有基因组内冲突分为三种类型的分类，根据基因是否不同意它们来自哪里，它们要去哪里，或者它们现在在哪里。我们举例说明这三个基本类别，调查和分类所有已知形式的基因组内冲突，并讨论对生物体适应不良和人类疾病的影响。
Recent years have seen an explosion of interest in genes that function for their own good and to the detriment of other genes that reside in the same genome. Such intragenomic conflicts are increasingly recognized to underpin maladaptation and disease. However, progress has been impeded by a lack of clear understanding regarding what intragenomic conflict actually means, and an associated obscurity concerning its fundamental drivers. Here we develop a general theory of intragenomic conflict in which genes are viewed as inclusive-fitness-maximizing agents that come into conflict when their inclusive-fitness interests disagree. This yields a classification of all intragenomic conflicts into three categories according to whether genes disagree about where they have come from, where they are going, or where they currently are. We illustrate each of these three basic categories, survey and classify all known forms of intragenomic conflict, and discuss the implications for organismal maladaptation and human disease.