Targeting neuroinflammation in neuropathic pain and opioid use.
Targeting neuroinflammation in neuropathic pain and opioid use.
复制标题
DOI：
10.1084/jem.20221244
复制
发表时间：
2023-02-06
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
Daniela Salvemini和Timothy Doyle讨论了在神经性疼痛治疗中靶向促炎神经免疫细胞相互作用的机会。神经性疼痛是由神经系统的损伤引起的。它影响了20%的美国成年人口，造成了重大的社会经济负担，但仍然非常难以治疗。目前的治疗方法疗效有限，副作用大，阻碍了他们有效治疗神经性疼痛的能力。过去30年的临床前研究已经确定了促炎神经免疫细胞相互作用在各种病因引起的神经性疼痛的发展和维持中的关键作用。促炎神经免疫细胞相互作用也是阿片类药物不良副作用的发展和其治疗疼痛功效丧失的基础。来自我们实验室和其他临床前动物模型的证据表明，生物活性鞘脂，鞘鞘醇-1-磷酸（S1P）通过S1P受体亚型1 （S1PR1）发出的信号调节神经免疫细胞相互作用。在这里，我们讨论如何靶向S1P/S1PR1信号与S1PR1拮抗剂已经批准或临床试验多发性硬化症可以提供一个可行的药物治疗方法，以减少神经免疫细胞炎症信号和潜在的治疗患者遭受神经性疼痛和阿片类药物的不良反应。
Daniela Salvemini and Timothy Doyle discuss the opportunity to target pro-inflammatory neuro-immune cell interactions in the treatment of neuropathic pain. Neuropathic pain arises from injuries to the nervous system. It affects 20% of the adult US population and poses a major socioeconomic burden yet remains exceedingly difficult to treat. Current therapeutic approaches have limited efficacy and a large side effect profile that impedes their ability to treat neuropathic pain effectively. Preclinical research over the last 30 yr has established the critical role that pro-inflammatory neuro–immune cell interactions have in the development and maintenance of neuropathic pain arising from various etiologies. Pro-inflammatory neuro–immune cell interactions also underlie the development of adverse side effects of opioids and the loss of their efficacy to treat pain. Evidence from work in our lab and others in preclinical animal models have shown that signaling from the bioactive sphingolipid, sphingosine-1-phosphate (S1P), through the S1P receptor subtype 1 (S1PR1) modulates neuro–immune cell interactions. Here, we discuss how targeting S1P/S1PR1 signaling with S1PR1 antagonists already Food and Drug Administration–approved or in clinical trials for multiple sclerosis can provide a viable pharmacotherapeutic approach to reduce neuro-immune cell inflammatory signaling and potentially treat patients suffering neuropathic pain and the adverse effects of opioids.
登录
查看更多内容
影响因子：
13.8
作者：
Squillace S;Spiegel S;Salvemini D
通讯作者：
Salvemini D
中枢神经系统中的鞘氨氨酸-1-磷酸受体1激活驱动顺铂诱导的认知障碍。
影响因子：
15.9
作者：
Squillace, Silvia;Niehoff, Michael L.;Doyle, Timothy M.;Green, Michael;Esposito, Emanuela;Cuzzocrea, Salvatore;Arnatt, Christopher K.;Spiegel, Sarah;Farr, Susan A.;Salvemini, Daniela
通讯作者：
Salvemini, Daniela
影响因子：
5
作者：
Grace PM;Maier SF;Watkins LR
通讯作者：
Watkins LR
影响因子：
7.4
作者：
Doolen S;Iannitti T;Donahue RR;Shaw BC;Grachen CM;Taylor BK
通讯作者：
Taylor BK
影响因子：
--
作者：
Singh, Sandeep K.;Spiegel, Sarah
通讯作者：
Spiegel, Sarah