In vitro studies on extracellular matrix production by M.leprae infected murine neurofibroblasts.
In vitro studies on extracellular matrix production by M.leprae infected murine neurofibroblasts.
复制标题
麻风分枝杆菌感染的小鼠神经成纤维细胞细胞外基质产生的体外研究。
作者：
N. Singh;T. Birdi;S. Chandrashekar;Antia Nh
成纤维细胞和大量巨噬细胞分泌产物与许多疾病有关，其中过量的细胞外基质（ECM）沉积是主要的病理特征。以胶原过度沉积为特征的纤维化也有助于麻风病中观察到的不可逆的神经损伤。自从M.麻风在疾病的晚期在神经成纤维细胞（Nf）中可见，并且巨噬细胞在所有阶段形成麻风神经的共同浸润细胞成分，在体外研究了在用M.麻风和存在巨噬细胞分泌产物。这些研究在来自两种小鼠品系的细胞中进行了比较，瑞士白色（SW）和C57 BL/6，因为它们对M的反应不同。麻风感染和平行的麻风瘤和结核样患者中观察到的分别。感染M. Nfs显示SW株IV型胶原和C57 B1/6株I型胶原分泌减少。巨噬细胞引起受M.而其他类型的胶原蛋白，即SW株中的I和III以及C57 Bl/s株中的III和IV，不受影响。本研究提示晚期麻风神经胶原化可能是神经纤维源性的。然而，与具有过量胶原沉积的其他疾病不同，由Nfs响应于神经损伤而产生的ECM蛋白在麻风神经病变的进展中可能不是最重要的，并且作为对麻风神经中细胞内容物损失的一般响应而发生。
Fibroblasts and a host of macrophage secretory products have been implicated in a number of diseases where excess extracellular matrix (ECM) deposition is the main pathological feature. Fibrosis characterized by excessive deposition of collagen also contributes to the irreversible nerve damage observed in leprosy. Since M. leprae are seen within neurofibroblasts (Nf) in the advanced stages of the disease and macrophages form a common infiltrating cellular constituent of leprous nerves at all stages, secretion of ECM proteins by Nf was studied, in vitro following infection with M. leprae and in the presence of macrophage secretory products. These studies were compared in cells derived from two strains of mice, Swiss White (SW) and C57BL/6, as they differ in their response to M. leprae infection and parallel those observed in lepromatous and tuberculoid patients, respectively. On infection with M. leprae, Nfs showed a decrease in secretion of collagen type IV in SW and type I in C57Bl/6 strain. Macrophages caused a further decrease in the secretion of collagen types affected by M. leprae infection per se, while the other collagen types, viz. I and III in SW strain and III and IV in C57Bl/s strain, were unaffected. This study indicates that neural collagenization in nerves in advanced leprosy may be of Nf origin. However, unlike other diseases with excess collagen deposition, ECM proteins produced by Nfs in response to nerve damage may not be of prime importance in the progression of leprous neuropathy and occur as a general response to loss of cellular content in leprous nerves.
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影响因子：
15.9
作者：
HIBBS, MS;HOIDAL, JR;KANG, AH
通讯作者：
KANG, AH
细胞外基质和生长因子：控制组织修复和疾病进展的综合相互作用。
DOI：
--
发表时间：
1993
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Haralson,MA
通讯作者：
Haralson,MA
白介素 1——麻风病神经纤维化的可能介质。
影响因子：
4.7
作者：
Band,H
通讯作者：
Band,H
脂多糖选择性上调人肺泡巨噬细胞胶原酶的产生，并与成纤维细胞产生胶原酶的比较。
DOI：
--
发表时间：
1988
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Cury,JD;Campbell,EJ;Lazarus,CJ;Albin,RJ;Welgus,HG
通讯作者：
Welgus,HG
影响肌营养不良小鼠背根神经节培养物雪旺细胞基底层形成的因素。
影响因子：
2.9
作者：
Cornbrooks,CJ;Mithen,F;Cochran,JM;Bunge,RP
通讯作者：
Bunge,RP