The Plot Thickens: Gelation by Phenylalanine in Water and Dimethyl Sulfoxide
The Plot Thickens: Gelation by Phenylalanine in Water and Dimethyl Sulfoxide
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DOI：
10.1021/acs.cgd.7b00213
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发表时间：
2017-08-01
影响因子：
3.8
通讯作者：
Lloyd, Gareth O.
中科院分区：
文献类型：
--
作者：
Nartowski, Karol P.;Ramalhete, Susana M.;Lloyd, Gareth O.
苯丙氨酸(Phe)是一种非常有兴趣的氨基酸，因为芳香基与手性亲水性区域的偶联赋予了许多独特的性质。最近，人们对这种化合物的晶体和凝胶形式越来越感兴趣，部分原因是所得材料的复杂和未确定的结构，以及Phe的固体形式与苯丙酮尿症的关系。在这份报告中，我们重点介绍了Phe的凝胶、结晶和自组装过程的动力学之间的关系。我们通过描述氨基酸的凝胶、凝胶与晶体的关系、对这种相对简单的化合物的晶体结构预测，以及在水和二甲基亚砜中由核磁共振确定的组装动力学来做到这一点。这将为未来研究苯丙酮尿症、苯丙酮尿症以及与淀粉样纤维形成相关的疾病提供指导。
Phenylalanine (Phe) is an amino acid of great interest as coupling of an aromatic group with a chiral hydrophilic region imparts a number of unique properties. Recently there has been an increased interest in the crystalline and gel forms of this compound, part as a result of the complex and undetermined structures of the resulting materials and the relationship of the solid forms of Phe with the disease phenylketonuria. In this report, we highlight the relationship between gelation, crystallization, and the dynamics of self assembly processes of Phe. We do this by describing the gelation of the amino acid, the gel to crystal relationship, crystal structure predictions for this relatively simple compound, and the dynamics of assembly as determined by NMR in both water and dimethyl sulfoxide. This will provide guidance to future research into Phe assemblies, possible treatments for pheylketonuria, and diseases related to formation of amyloid-like fibers.