Convection-enhanced delivery in glioblastoma: a review of preclinical and clinical studies.
Convection-enhanced delivery in glioblastoma: a review of preclinical and clinical studies.
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胶质母细胞瘤中对流增强的递送：临床前和临床研究的综述。
DOI：
10.3171/2016.1.jns151591
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发表时间：
2017-01
影响因子：
4.1
通讯作者：
Aghi MK
中科院分区：
文献类型：
--
作者：
Jahangiri A;Chin AT;Flanigan PM;Chen R;Bankiewicz K;Aghi MK
胶质母细胞瘤是最常见的恶性脑肿瘤，预后极差。由于血脑屏障阻止了许多药物到达肿瘤细胞，开发靶向治疗的尝试一直受到阻碍。此外，药物的全身毒性往往限制了它们的治疗潜力。已经开发了许多替代的输送方法，其中之一是对流增强输送（CED），这是本文的重点。作者将CED描述为一种治疗措施，并回顾了CED治疗胶质母细胞瘤的临床前研究和最突出的临床试验。介绍了该技术在多种药剂输送中的应用，并详细讨论了其缺点和挑战。
Glioblastoma is the most common malignant brain tumor, and it carries an extremely poor prognosis. Attempts to develop targeted therapies have been hindered because the blood-brain barrier prevents many drugs from reaching tumors cells. Furthermore, systemic toxicity of drugs often limits their therapeutic potential. A number of alternative methods of delivery have been developed, one of which is convection-enhanced delivery (CED), the focus of this review. The authors describe CED as a therapeutic measure and review preclinical studies and the most prominent clinical trials of CED in the treatment of glioblastoma. The utilization of this technique for the delivery of a variety of agents is covered, and its shortcomings and challenges are discussed in detail.