PATHOLOGIC FEATURES OF MUSCLE IN SYSTEMIC LUPUS-ERYTHEMATOSUS - A BIOPSY SERIES WITH COMPARATIVE CLINICAL AND IMMUNOPATHOLOGIC OBSERVATIONS
PATHOLOGIC FEATURES OF MUSCLE IN SYSTEMIC LUPUS-ERYTHEMATOSUS - A BIOPSY SERIES WITH COMPARATIVE CLINICAL AND IMMUNOPATHOLOGIC OBSERVATIONS
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DOI：
10.1016/s0046-8177(82)80298-0
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发表时间：
1982-01-01
期刊：
影响因子：
3.3
通讯作者：
IRVIN, W
中科院分区：
文献类型：
--
作者：
OXENHANDLER, R;HART, MN;IRVIN, W
骨骼肌受累的临床证据是常见的系统性红斑狼疮（SLE）。为了解系统性红斑狼疮（SLE）的骨骼肌表现，对19例SLE患者的骨骼肌进行了组织学、组织化学和直接免疫荧光染色研究。结果与临床和实验室数据相关。组织学谱包括炎性肌病、血管炎、束周萎缩和神经源性萎缩。组织化学检查显示44%的患者I型纤维占优势，33%的患者选择性II型纤维萎缩。骨骼肌活检标本的直接免疫荧光检查显示血管壁、肌膜基底膜区域和非坏死肌纤维内有IG和补体沉积。组织学、组织化学和免疫组化结果与其他器官系统的结果相关。
Clinical evidence of skeletal muscle involvement is frequent in systemic lupus erythematosus (SLE). To characterize the manifestations of SLE in skeletal muscle, a biopsy series on 19 patients with SLE was studied in terms of the histologic, histochemical and direct immunofluorescent features of skeletal muscle. Results were correlated with clinical and laboratory data. The histologic spectrum included inflammatory myopathy, vasculitis, perifascicular atrophy and neurogenic atrophy. Histochemical examination revealed type I fiber predominance in 44% of patients and selective type II fiber atrophy in 33%. Direct immunofluorescent examination of skeletal muscle biopsy specimens revealed Ig and complement deposition in vessel walls, in sarcolemmal basement membrane areas and within non-necrotic muscle fibers. The histologic, histochemical and immunochemical findings are correlated with the findings in other organ systems.