Association between intakes of magnesium, potassium, and calcium and risk of stroke: 2 cohorts of US women and updated meta-analyses
Association between intakes of magnesium, potassium, and calcium and risk of stroke: 2 cohorts of US women and updated meta-analyses
复制标题
DOI：
10.3945/ajcn.114.100354
复制
发表时间：
2015-06-01
影响因子：
7.1
通讯作者：
Rexrode, Kathryn M.
中科院分区：
文献类型：
--
作者：
Adebamowo, Sally N.;Spiegelman, Donna;Rexrode, Kathryn M.
背景：镁、钾和钙摄入与卒中风险关系的前瞻性数据不一致，据我们所知，联合矿物质饮食评分的影响尚未得到检验。目的：我们研究了护士健康研究（NHS） I中86149名女性和NHS II中94715名女性的镁、钾和钙摄入量与卒中发生风险之间的关系。设计：在这项前瞻性队列研究中，我们通过使用多变量Cox比例风险模型，按每种矿物质摄入量的五分位数计算中风的hr，并对所有3种矿物质的综合饮食评分进行计算。此外，我们更新了这些矿物质的膳食摄入量和中风风险的荟萃分析。结果：在随访期间（NHS I组30年；NHS II组22年），共记录了3780例卒中事件。与最低五分位数的女性相比，最高五分位数的女性总卒中的多因素综合风险比为：总镁摄入0.87 (95% CI: 0.78, 0.97)，总钾摄入0.89 (95% CI: 0.80, 0.99)，总钙摄入0.97 （95% CI: 0.87, 1.09）。综合矿物质饮食评分最高和最低五分位数的女性的总卒中总风险比为0.72 (95% CI: 0.65, 0.81)，缺血性卒中总风险比为0.78 (95% CI: 0.66, 0.92)，出血性卒中总风险比为0.80 （95% CI: 0.61, 1.04）。在迄今为止所有前瞻性研究的最新荟萃分析中，镁摄入量增加100 mg/d的总卒中的综合RR为0.87 (95% CI: 0.83, 0.92)，钾摄入量增加1000 mg/d的总卒中总RR为0.91 (95% CI: 0.88, 0.94)，钙摄入量增加300 mg/d的总卒中总RR为0.98 （95% CI: 0.94, 1.02）。结论：综合矿物质饮食评分与卒中风险呈负相关。大量摄入镁和钾而不是钙也与降低女性中风风险显著相关。
Background: Prospective data on the relation of magnesium, potassium, and calcium intakes with stroke risk are inconsistent, and to our knowledge, the effect of a combined mineral diet score has not been examined.Objective: We examined associations between intakes of magnesium, potassium, and calcium and risk of incident stroke in 86,149 women in the Nurses' Health Study (NHS) I and 94,715 women in the NHS II.Design: In this prospective cohort study, we calculated HRs of stroke by quintiles of intake for each mineral and for a combined diet score of all 3 minerals by using multivariate Cox proportional hazard models. In addition, we updated meta-analyses on dietary intakes of these minerals and risk of stroke.Results: During follow-up (30 y in the NHS I; 22 y in the NHS II) a total of 3780 incident stroke cases were documented. Pooled multivariate RRs of total stroke for women in the highest compared with the lowest quintiles were 0.87 (95% CI: 0.78, 0.97) for total magnesium, 0.89 (95% CI: 0.80, 0.99) for total potassium, and 0.97 (95% CI: 0.87, 1.09) for total calcium intake. Pooled RRs for women in the highest compared with the lowest quintiles of a combined mineral diet score were 0.72 (95% CI: 0.65, 0.81) for total stroke, 0.78 (95% CI: 0.66, 0.92) for ischemic stroke, and 0.80 (95% CI: 0.61, 1.04) for hemorrhagic stroke. In the updated meta-analyses of all prospective studies to date, the combined RR of total stroke was 0.87 (95% CI: 0.83, 0.92) for a 100-mg/d increase in magnesium intake, 0.91 (95% CI: 0.88, 0.94) for a 1000-mg/d increase in potassium intake, and 0.98 (95% CI: 0.94, 1.02) for a 300-mg/d increase in calcium intake.Conclusions: A combined mineral diet score was inversely associated with risk of stroke. High intakes of magnesium and potassium but not calcium were also significantly associated with reduced risk of stroke in women.