Potential of Excipient Emulsions for Improving Quercetin Bioaccessibility and Antioxidant Activity: An in Vitro Study
Potential of Excipient Emulsions for Improving Quercetin Bioaccessibility and Antioxidant Activity: An in Vitro Study
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赋形剂乳液改善槲皮素生物可及性和抗氧化活性的潜力：体外研究
DOI：
10.1021/acs.jafc.6b01056
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发表时间：
2016-05-11
影响因子：
6.1
通讯作者：
McClements, David Julian
中科院分区：
文献类型：
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作者：
Chen, Xing;Zou, Liqiang;McClements, David Julian
本研究确定了赋形剂乳剂增强槲皮素生物可及性和抗氧化活性的潜力。由长链甘油三酯（玉米油）制备含有两种水平（4或10%）小脂滴（d < 250 nm）的水包油赋形剂乳剂。赋形剂乳剂对槲皮素的增溶速度快于散装玉米油或散装水，100 ℃时的增溶速率高于30 ℃时的增溶速率。使用体外胃肠道模型测定槲皮素样品的生物可及性，并使用大鼠喂养研究测定槲皮素的生物活性。赋形剂乳剂在增强槲皮素生物可及性和大鼠血浆抗氧化活性方面比散装油或散装水更有效。这种效应归因于长链甘油三酯在乳化形式时的快速消化，这导致能够溶解、保护和运输槲皮素的混合胶束的快速产生。
The potential for excipient emulsions to enhance the bioaccessibility and antioxidant activity of quercetin was determined in this study. Oil-in-water excipient emulsions containing two levels (4 or 10%) of small lipid droplets (d < 250 nm) were prepared from a long-chain triglyceride (corn oil). The solubilization of quercetin by the excipient emulsions was faster than by bulk corn oil or bulk water, and the solubilization rate was higher at 100 degrees C than at 30 degrees C. The bioaccessibility of quercetin samples was determined using an in vitro gastrointestinal model, and the bioactivity of quercetin was determined using a rat feeding study. The excipient emulsions were more effective at enhancing quercetin bioaccessibility and rat plasma antioxidant activity than either bulk oil or bulk water. This effect was attributed to the rapid digestion of the long chain triglycerides when they were in an emulsified form, which led to the rapid production of mixed micelles capable of solubilizing, protecting, and transporting quercetin.