Dose-volumetric parameters for predicting severe radiation pneumonitis after three-dimensional conformal radiation therapy for lung cancer
Dose-volumetric parameters for predicting severe radiation pneumonitis after three-dimensional conformal radiation therapy for lung cancer
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DOI：
10.1148/radiol.2351040248
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发表时间：
2005-04-01
期刊：
影响因子：
19.7
通讯作者：
Kim, DY
中科院分区：
文献类型：
--
作者：
Kim, TH;Cho, KH;Kim, DY
目的：回顾性评估剂量 - 体积参数与肺癌患者接受三维（3D）适形放疗后发生严重（3级）放射性肺炎（RP）风险的相关性。
材料与方法：本研究经机构审查委员会批准，无需知情同意。回顾性分析2001年8月至2002年10月期间76例经组织学证实的肺癌患者的数据，其中男性66例，女性10例；中位年龄60岁（范围35 - 79岁），这些患者接受了3D适形放疗进行根治性治疗。20例患者在放疗前接受了手术；57例患者接受了化疗。中位总放疗剂量为60 Gy（范围54 - 66 Gy），分30次（范围27 - 33次）在6周内给予。采用放射治疗肿瘤学组标准对放射性肺炎进行评分。分析临床参数。分析的剂量 - 体积参数包括接受20 Gy及以上剂量的肺体积百分比（V20）、30 Gy及以上（V30）、40 Gy及以上（V40）或50 Gy及以上（V50）；平均肺剂量（MLD）；正常组织并发症概率（NTCP）以及总剂量。采用Fisher精确检验比较发生严重放射性肺炎的患者和未发生的患者之间的临床参数。进行单变量和多变量逻辑回归分析以评估剂量 - 体积参数与严重放射性肺炎之间的相关性数据。采用Pearson卡方检验评估剂量 - 体积参数之间的相关性数据。P（此处似乎内容不完整）
PURPOSE: To retrospectively evaluate dose-volumptric parameters for association with risk of severe (grade :3) radiation pneumonitis (RP) in patients after three-dimensional (31)) conformal radiation therapy for lung cancer.MATERIALS AND METHODS: The study was approved by the institutional review board, which did not require informed consent. Data from 76 patients (66 men, 10 women; median age, 60 years; range, 35-79 years) with histologically proved lung cancer treated curatively with 3D conformal radiation therapy between August 2001 and October 2002 were retrospectively analyzed. Twenty patients underwent surgery before radiation therapy; 57 patients received chemotherapy Median total. radiation dose of 60 Gy (range, 54-66 Gy) was delivered in 30 (range, 27-33) fractions over 6 weeks. RP was scored by using Radiation Therapy Oncology Group criteria. Clinical parameters were analyzed. Dose-volumetric parameters analyzed were percentage of lung volume that received a dose of 20 Gy or more (V20), 30 Gy or more (V30), 40 Gy or more (V40), or 50 Gy or more (V50); mean lung dose (MLD); normal tissue complication probability (NTCP); and total dose. Fisher exact test was performed to compare clinical parameters between patients who developed severe RP and those who did not. Univariate and multivariate logistic regression analyses were performed to evaluate data for association between dose-volumetric parameters and severe RP. Pearson chi(2) test was used to assess data for correlations among close-volumetric parameters. P