13?N-ammonia PET-derived right ventricular longitudinal strain and myocardial flow reserve in right coronary artery disease
13?N-ammonia PET-derived right ventricular longitudinal strain and myocardial flow reserve in right coronary artery disease
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13?N-氨 PET 衍生的右心室纵向应变和右冠状动脉疾病中的心肌血流储备
DOI：
10.1007/s00259-021-05647-y
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发表时间：
2021
影响因子：
9.1
通讯作者：
Sakai Shuji
中科院分区：
文献类型：
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作者：
Kawakubo Masateru;Nagao Michinobu;Yamamoto Atsushi;Nakao Risako;Matsuo Yuka;Kaneko Koichiro;Watanabe Eri;Sakai Akiko;Sasaki Masayuki;Sakai Shuji
目的我们开发了一种用于心电门控高分辨率13 N-氨正电子发射断层扫描（PET）成像的特征跟踪算法，我们假设它可以用于阐明右心室（RV）纵向应变（LS）和右冠状动脉（RCA）缺血之间的关系。本研究的目的是探讨区域性心肌血流储备（MFR）在RCA领土和PET衍生LS的RV free wall. MethodsNine 3例冠状动脉狭窄> 50%，冠状动脉CT血管造影诊断，和10个对照组之间的关联进行了回顾性分析。在水平长轴切片的静息和应激13 N-氨PET图像上，通过特征跟踪技术测量游离壁的RV-LS。根据RCA、左前降支（LAD）和左回旋支冠状动脉（LCx）区域的区域MFR值对患者进行亚组：RCA-MFR <2. 0 [n= 34]，RCA-MFR ≥ 2. 0但LAD或LCx区域的MFR <2. 0 [n= 11]，所有区域的MFR ≥ 2. 0 [n= 48]。在四组中的每一组中比较应激和静息RV-LS。四组之间的RV-LS的多重比较进行了在应力和静息状态。ResultsReduced应力RV-LS的患者与RCA-MFR < 2.0观察。在所有区域MFR ≥ 2.0的患者中，与静息状态相比，应激RV-LS显著增加。显著降低右心室游离壁LS腺苷负荷与RCA-MFR < 2.0的患者观察在其他三group.ConclusionsWe测量右心室心肌LS使用功能跟踪电影成像的13 N-氨PET。这项研究的结果表明，PET衍生的应激RV-LS可用于检测由于RCA区域缺血导致的RV心肌运动减少。
PurposeWe developed a feature-tracking algorithm for use with electrocardiography-gated high-resolution13N-ammonia positron emission tomography (PET) imaging, and we hypothesized it could be used to clarify the association between right ventricular (RV) longitudinal strain (LS) and right coronary artery (RCA) ischemia. The aim of this study was to investigate the association between the reduction of regional myocardial flow reserve (MFR) in RCA territories and PET-derived LS of the RV free wall.MethodsNinety-three patients with coronary artery stenosis > 50%, diagnosed by coronary computed tomography angiography, and 10 controls were retrospectively analyzed. RV-LS in the free wall was measured by a feature-tracking technique on the resting and stressed13N-ammonia PET images of horizontal long axis slices. The patients were sub-grouped according to regional MFR values at the territories of RCA, left anterior descending artery (LAD), and left circumflex coronary artery (LCx): RCA-MFR < 2.0 [n= 34], RCA-MFR ≥ 2.0 but MFR < 2.0 at LAD or LCx territories [n= 11], and MFR ≥ 2.0 for all territories [n= 48]. Stress and resting RV-LS were compared in each of the four groups. Multiple comparisons of RV-LS among the four groups were performed in the stress and resting state.ResultsDecreased stress RV-LS in patients with an RCA-MFR < 2.0 was observed. In the patients with MFR ≥ 2.0 for all territories, the stressed RV-LS was significantly increased compared to that in the resting state. Significantly decreased RV free wall LS during adenosine stress in patients with RCA-MFR < 2.0 was observed in the other three groups.ConclusionsWe measured RV myocardial LS using feature tracking in cine imaging of13N-ammonia PET. The results of this study suggest that PET-derived stressed RV-LS is useful for detecting reduced RV myocardial motion due to ischemia in the RCA territory.