Life-course trajectories of body mass index and subsequent cardiovascular risk among Chinese population
Life-course trajectories of body mass index and subsequent cardiovascular risk among Chinese population
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DOI：
10.1371/journal.pone.0223778
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发表时间：
2019-10-10
期刊：
影响因子：
3.7
通讯作者：
Liang, Yajun
中科院分区：
文献类型：
--
作者：
Islam, Md Tauhidul;Moller, Jette;Liang, Yajun
研究身体质量指数（BMI）在生命过程中的变化对于促进和预防心血管健康至关重要。到目前为止，很少有证据表明BMI从童年到晚年的长期变化。这项研究旨在检查BMI的生命轨迹模式，然后将轨迹模式与成年期心血管风险因素联系起来。方法基于中国健康与营养调查（China Health and Nutrition Survey）的纵向数据，选取1989年基线（6-60岁）的5276名参与者（1989-2009年），他们在1989-2009年期间进行了多达7项BMI测量。2009年对2411名参与者的心血管危险因素包括高血压、高血糖和高血脂进行了评估。使用潜在生长曲线模型分析BMI轨迹，并使用逻辑回归来检查轨迹模式与心血管危险因素之间的关联。结果6 ~ 80岁人群BMI有4种轨迹模式：正常-稳定（22.4%）、低正常-正常-稳定（44.1%）、低正常-正常超重（27.2%）和超重-肥胖（4.3%）。与正常-稳定模式的人相比，低正常-正常-稳定模式、低正常-正常-超重模式和超重-肥胖模式的人患高血压（优势比范围为1.6-6.6）、高血糖（优势比范围为1.7-9.1）、血脂异常（优势比范围为2.6-5.9）和至少有三种心血管危险因素中的两种（优势比为3.9-30.9）的风险更高。结论终生BMI稳定在正常范围内与心血管风险最低相关，而终生超重和肥胖与心血管风险最高相关。
BackgroundExamining body mass index (BMI) change over life course is crucial for cardiovascular health promotion and prevention. So far, there is very few evidence on the long-term change of BMI from childhood to late life. This study aimed to examine the life-course trajectory patterns of BMI and then to link the trajectory patterns to cardiovascular risk factors in adulthood.MethodsBased on longitudinal data from the China Health and Nutrition Survey, 5276 participants (aged 6-60) at baseline (in 1989) with up to 7 measurements of BMI during 1989-2009 were selected in this study. Cardiovascular risk factors including high blood pressure, high blood glucose and high blood lipids were assessed in 2411 participants in 2009. Latent growth curve modelling was used to analyse the BMI trajectories, and logistic regression was used to examine the associations between trajectory patterns and cardiovascular risk factors.ResultsFour trajectories patterns of BMI over life course (age 6-80) were identified: Normal-Stable (22.4% of the total participants), Low normal-Normal-Stable (44.1%), Low normal-NormalOverweight (27.2%), and Overweight-Obese (4.3%). Compared to those with Normal-Stable pattern, those with Low normal-Normal-Stable pattern, Low normal-Normal-Overweight pattern and Overweight-Obese pattern had higher risk of high blood pressure (odds ratio range = 1.6-6.6), high blood glucose (1.7-9.1), dyslipidemia (2.6-5.9) and having at least two of the three cardiovascular risk factors (3.9-30.9).ConclusionsHaving a stable BMI within normal range over life course is associated with the lowest cardiovascular risk, whereas remaining overweight and obese over life course is associated with the highest cardiovascular risk.