Facile Synthesis of Hollow Mesoporous Silica Microspheres via Surface Sol-Gel Process on Functional Polymeric Microsphere Template
Facile Synthesis of Hollow Mesoporous Silica Microspheres via Surface Sol-Gel Process on Functional Polymeric Microsphere Template
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在功能聚合物微球模板上通过表面溶胶-凝胶法轻松合成中空介孔二氧化硅微球
DOI：
10.1166/jnn.2016.12946
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发表时间：
2016
影响因子：
--
通讯作者：
Li Na
中科院分区：
文献类型：
--
作者：
Liu Weiwei;Zhang Yaoyao;Xu Jianxiong;Xu Lijian;Du Jingjing;Li Na
以聚苯乙烯-N-（4-乙烯基苄基）-N，N-二乙基胺盐酸盐共聚物（PS-co-PVEAH）为核壳结构的功能化聚合物微球为模板，正硅酸乙酯（TEOS）为硅源，在十六烷基三甲基溴化铵存在下合成了中空介孔二氧化硅微球。由于刘易斯碱性PVEAH链段在PS-co-PVEAH核壳微球的模板表面上的固有作用，溶胶-凝胶正硅酸乙酯（TEOS）过程仅针对模板，避免了不需要的和不规则的聚集体的形成，因此制备了良好限定的HMSM。通过透射电子显微镜（TEM）、傅里叶变换红外光谱（FTIR）和氮气吸附-脱附分析等技术对产物进行了表征。结果表明，在可控的条件下，可以合成出粒径在256 nm ~ 148 nm、壳层厚度在9 nm ~ 16 nm的HMSM。所获得的高分子自组装膜有望在生物医学领域得到应用，如酶的固定化、纳米药物递送系统、蛋白质分离等。
A facile and effective route has been developed in this study for synthesis of hollow mesoporous silica microspheres (HMSMs), by employing functional core–shell polymeric polystyrene-co-poly (N-(4-vinylbenzyl)-N,N-diethylamine hydrochloride) (PS-co-PVEAH) microspheres as template and tetraethoxysilane (TEOS) as silica source in the presence of cetyltrimethylammonium bromide. Due to inherent action of Lewis alkaline PVEAH segment on the template surface of the PS-co-PVEAH core–shell microspheres, the sol–gel tetraethyl orthosilicate (TEOS) process was directed exclusively onto the template, avoiding the formation of unwanted and irregular aggregates and therefore well-defined HMSMs were fabricated. The products were characterized by various techniques, including transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy and nitrogen adsorption–desorption analysis. Results demonstrated that the HMSMs with size ranging from 256 nm to 148 nm and shell thickness from 9 nm to 16 nm could be synthesized at controlled manner. The obtained HMSMs are anticipated to be good candidates for biomedical applications, such as enzyme immobilization, nano-drug delivery system, protein separation, etc.