Genetic structure of the purebred domestic dog
Genetic structure of the purebred domestic dog
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DOI：
10.1126/science.1097406
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发表时间：
2004-05-21
期刊：
影响因子：
56.9
通讯作者：
Kruglyak, L
中科院分区：
文献类型：
--
作者：
Parker, HG;Kim, LV;Kruglyak, L
我们使用分子标记来研究 85 个家养犬品种的遗传关系。品种间的差异约占遗传变异的30%。微卫星基因型用于将 99% 的狗个体正确分配到品种。系统发育分析将几个具有古代起源的品种与其余具有现代欧洲起源的品种分开。我们确定了四个遗传簇，其中主要包含具有相似地理起源、形态或在人类活动中的作用的品种。这些结果提供了狗品种的遗传分类，并将有助于研究表型品种差异的遗传学。
We used molecular markers to study genetic relationships in a diverse collection of 85 domestic dog breeds. Differences among breeds accounted for similar to 30% of genetic variation. Microsatellite genotypes were used to correctly assign 99% of individual dogs to breeds. Phylogenetic analysis separated several breeds with ancient origins from the remaining breeds with modern European origins. We identified four genetic clusters, which predominantly contained breeds with similar geographic origin, morphology, or role in human activities. These results provide a genetic classification of dog breeds and will aid studies of the genetics of phenotypic breed differences.