Relating pessimistic memory predictions to Alzheimer's disease brain structure
Relating pessimistic memory predictions to Alzheimer's disease brain structure
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DOI：
10.1016/j.cortex.2016.09.014
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发表时间：
2016-12-01
期刊：
影响因子：
3.6
通讯作者：
Salmon, Eric
中科院分区：
文献类型：
--
作者：
Genon, Sarah;Simon, Jessica;Salmon, Eric
阿尔茨海默病（AD）患者表现出情景记忆和相关元认知过程的损害。本研究考察了AD患者在客观记忆提取前的主观元认知判断，并研究了AD患者成功提取记忆的悲观预测的神经相关性。AD患者和健康老年人（HO）参与者在提取著名（语义）和最近学习（情节）的名字之前，对他们的识别性能提供了预测判断。采用偏最小二乘法（PLS）和一般线性模型（GLM）分析了AD患者T1图像上的灰质体积（GMV）与行为评分之间的相关性。偏最小二乘法（PLS）结果显示，AD患者的行为模式与GMV下降的右侧模式有关，主要包括内侧颞叶和后扣带皮层（PCC），也包括右侧腹外侧前额叶皮层（VLPFC）。GLM进一步证实，悲观预测与VLPFC的GMV呈负相关，因此，AD患者VLPFC的GMV降低主要与对自身记忆表现进行推断的监控过程受损（可能受不准确信念的影响）有关。(C)2016爱思唯尔有限公司版权所有
Patients with Alzheimer's disease (AD) show impairment of episodic memory and related metacognitive processes. The present study examined subjective metacognitive judgments preceding objective memory retrieval and investigated the neural correlates of pessimistic predictions for successfully retrieved memories in AD patients.AD patients and healthy older (HO) participants provided predictive judgments on their recognition performance before retrieval of famous (semantic) and recently learned (episodic) names. Correlations between gray matter volume (GMV) in T1 images and behavioral scores were examined with multivariate (partial least square - PLS) and univariate (general linear model - GLM) analyses in AD patients.AD patients showed a significant proportion of successful name recognition preceded by pessimistic prediction in episodic memory. PLS revealed that the behavioral pattern in AD patients was related with a mainly right lateralized pattern of GMV decrease including medial temporal lobe and posterior cingulate cortex (PCC), but also right Ventrolateral prefrontal cortex (VLPFC). GLM further confirmed that pessimistic prediction negatively correlated with GMV in VLPFC.Thus, impaired monitoring processes (possibly influenced by inaccurate beliefs) allowing inferences about one's own memory performance are primarily related to decrease GMV in VLPFC in AD patients. (C) 2016 Elsevier Ltd. All rights reserved.