Keloids: The paradigm of skin fibrosis - Pathomechanisms and treatment.
Keloids: The paradigm of skin fibrosis - Pathomechanisms and treatment.
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DOI：
10.1016/j.matbio.2016.01.013
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发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Uitto J
中科院分区：
文献类型：
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作者：
Andrews JP;Marttala J;Macarak E;Rosenbloom J;Uitto J
瘢痕疙瘩是一种纤维增生性皮肤肿瘤，细胞外基质（ECM）成分，特别是胶原蛋白的渗出性积累，是生长因子和细胞因子过度表达的结果。瘢痕疙瘩的病因尚不清楚，但它们发生在遗传易感个体的皮肤损伤后，并且它们对受影响的个体造成身体和心理上的痛苦。瘢痕疙瘩有几种治疗方法，包括手术切口和病灶内类固醇治疗的联合治疗，然而，无论目前的治疗方法如何，它们的复发率都很高。对导致瘢痕疙瘩形成的病理机制的进一步理解将有望确定作为特定靶点的途径，以改善对这种破坏性的、目前难以治疗的疾病的治疗。
Keloids, fibroproliferative dermal tumors with effusive accumulation of extracellular matrix (ECM) components, particularly collagen, result from excessive expression of growth factors and cytokines. The etiology of keloids is unknown but they occur after dermal injury in genetically susceptible individuals, and they cause both physical and psychological distress for the affected individuals. Several treatment methods for keloids exist, including the combination therapy of surgical incision followed by intralesional steroid therapy, however, they have high recurrence rate regardless of the current treatment method. Improved understanding of the pathomechanisms leading to keloid formation will hopefully identify pathways that serve as specific targets to improve therapy for this devastating, currently intractable, disorder.