Development of the brain stem in the rat. IV. Thymidine‐radiographic study of the time of orgin of neurons in the pontine region
Development of the brain stem in the rat. IV. Thymidine‐radiographic study of the time of orgin of neurons in the pontine region
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大鼠脑干的发育 IV。胸苷放射学研究脑桥区域神经元的起源时间。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
S. A. Bayer
中科院分区：
文献类型：
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作者：
J. Altman;S. A. Bayer
从妊娠第12天和第13天（E12 + 13）至分娩前一天（E21 + 22），连续每天两次向妊娠大鼠组注射3 H-胸苷，以标记其胚胎中神经元的增殖前体。在60天的年龄的神经元的比例产生（或不再标记）在特定的胚胎天定量测定脑桥区的14个核。三叉神经中脑核的神经元的峰值产生时间是在E11天或更早，与E12天产生的一小部分。三叉神经运动神经元的峰值产生时间是在E12天，有一小部分产生更早。主要感觉核的神经元在E13和E16天之间产生，在E14天达到高峰;晚期产生的神经元往往属于一类中型和大型细胞。大部分三叉神经上核和三叉神经下核的神经元在E15和E16天出现。
Groups of pregnant rats ware injected with two successive daily doses of 3H‐thymidine form gestational day 12 and 13 (E12 + 13) until the day before parturition (E21 + 22) in order to label in their embryos the proliferating precursors of neurons. At 60 days of age the proportion of neurons generated (or no longer labeled) on specific embryonic days was determined quantitatively in 14 nuclei of the pontine region. Peak production time of neurons of the trigeminal mesencephalic nucleus was on day E11 or earlier, with a small proportion generated on day E12. Peak production time of the trigeminal motor neurons was on day E12, with a small proportion produced earlier. Neurons of the principal sensory nucleus were generated between days E13 and E16, with a peak on day E14; the late‐produced neurons tended to belong to a class of intermediate and large cells. The bulk of the neurons of the supratrigeminal and infratrigeminal nuclei arose on day E15 and E16.