Computed tomography score and pulmonary function in infants with chronic lung disease of infancy.
Computed tomography score and pulmonary function in infants with chronic lung disease of infancy.
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DOI：
10.1183/09031936.00172310
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发表时间：
2011-10
期刊：
影响因子：
--
通讯作者：
Tepper RS
中科院分区：
文献类型：
--
作者：
Sarria EE;Mattiello R;Rao L;Wanner MR;Raske ME;Tiller C;Kimmel R;Tepper RS
婴儿慢性肺病（CLDI）仍然是极早产儿的常见结局。在患有肺部疾病的年龄较大的儿童和成人中，肺功能和计算机断层扫描（CT）评分用于随访呼吸系统疾病并评估疾病严重程度。然而，对于婴儿和幼儿，这些结果很少使用，最常见的是采用二分呼吸结果（存在或不存在CLDI）。我们评估了CT评分和肺功能的表现，以区分患有CLDI的婴儿和幼儿与对照组。对39例CLDI患者和41例对照者（年龄4-33个月）进行CT扫描、用力呼气流量和肺弥散功能检查。使用评分系统对CT扫描进行量化，而肺功能表示为Z分数。CT评分在识别CLDI患者方面优于肺功能。CT评分与肺功能无明显相关性。CT评分在区分CLDI个体方面的表现优于肺功能;然而，这些结果可能反映了CLDI肺病理生理学的不同组成部分。这些关于肺部结局的新信息可以帮助设计具有这些参数的研究。未来的研究将需要评估哪些结果可以更好地检测治疗干预和/或肺生长的改善。
Chronic lung disease of infancy (CLDI) remains a common outcome among infants born extremely prematurely. In older children and adults with lung disease, pulmonary function and computed tomography (CT) scores are used to follow up respiratory disease and assess disease severity. For infants and toddlers, however, these outcomes have been used very infrequently and most often, a dichotomous respiratory outcome (presence or absence of CLDI) is employed. We evaluated the performance of CT score and pulmonary function to differentiate infants and toddlers with CLDI from a control group. CT scans, forced expiratory flows and pulmonary diffusing capacity were obtained in 39 CLDI patients and 41 controls (aged 4–33 months). CT scans were quantified using a scoring system, while pulmonary function was expressed as Z-scores. CT score outperformed pulmonary function in identifying those with CLDI. There were no significant correlations between CT score and pulmonary function. CT score had a better performance than pulmonary function in differentiating individuals with CLDI; however, these outcomes may reflect differing components of the pulmonary pathophysiology of CLDI. This new information on pulmonary outcomes can assist in designing studies with these parameters. Future studies will be required to evaluate which of the outcomes can better detect improvement with therapeutic intervention and/or lung growth.
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DOI：
10.1164/rccm.200809-1523oc
发表时间：
2009-08-15
影响因子：
24.7
作者：
Narang, Indra;Bush, Andrew;Rosenthal, Mark
通讯作者：
Rosenthal, Mark
DOI：
10.1513/pats.200801-012aw
发表时间：
2008-08-15
期刊：
Proceedings of the American Thoracic Society
影响因子：
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作者：
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通讯作者：
Driscoll, Barbara
DOI：
10.1164/rccm.200908-1190oc
发表时间：
2010-05-15
影响因子：
24.7
作者：
Balinotti, Juan E.;Chakr, Valentina C.;Tepper, Robert S.
通讯作者：
Tepper, Robert S.
DOI：
10.1164/rccm.200705-701oc
发表时间：
2008-07-01
影响因子：
24.7
作者：
Narang, Indra;Rosenthal, Mark;Bush, Andrew
通讯作者：
Bush, Andrew
影响因子：
5
作者：
OPPENHEIM, C;MAMOUMANI, T;LALLEMAND, D
通讯作者：
LALLEMAND, D