Clinical correlates of interferon gamma production in patients with tuberculosis
Clinical correlates of interferon gamma production in patients with tuberculosis
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DOI：
10.1086/513769
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发表时间：
1997-09-01
影响因子：
11.8
通讯作者：
Barnes, PF
中科院分区：
文献类型：
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作者：
Sodhi, A;Gong, JH;Barnes, PF
为了确定产生干扰素（IFN）γ的能力是否与结核病的临床表现有关，我们将结核分枝杆菌诱导的外周血单核细胞（PBMC）产生IFN-γ与63例人类免疫缺陷病毒（HIV）阴性和43例HIV阳性结核病患者的临床、放射学和实验室变量相关联，对于胸片显示中度晚期疾病的HIV阴性患者，平均IFN-γ浓度+/- SD为1，639 +/- 388 pg/mL，而对于极晚期疾病患者，平均IFN-γ浓度为327 +/- 100 pg/mL（P = 0.0001），对于仅患有胸膜肺疾病的HIV感染患者，平均IFN-γ浓度为1，002 +/- 257 pg/mL，而患有肺和胸膜以外疾病的患者为149 +/- 55 pg/mL（P = 0.0004）。多变量分析证实，影像学疾病范围和疾病部位是HIV阴性和HIV感染患者IFN-γ产生的唯一独立预测因素（P小于或等于0.001）。我们的结论是，减少IFN-γ产生的PBMC是一个严重的结核病在HIV阴性和HIV感染的结核病患者的标志。
To determine if the capacity to produce interferon (IFN) gamma is related to the clinical manifestations of tuberculosis, we correlated Mycobacterium tuberculosis-induced IFN-gamma production by peripheral blood mononuclear cells (PBMCs) with clinical, radiographic, and laboratory variables for 63 human immunodeficiency virus (HIV)-negative patients and 43 HIV-positive patients with tuberculosis, For HIV-negative patients whose chest radiographs showed moderately advanced disease, the mean IFN-gamma concentration +/- SD was 1,639 +/- 388 pg/mL, whereas that for patients with far-advanced disease was 327 +/- 100 pg/mL (P =.0001), For HIV-infected patients who had only pleuropulmonary disease, the mean IFN-gamma concentration was 1,002 +/- 257 pg/mL, whereas that for patients with disease outside the lungs and pleura was 149 +/- 55 pg/mL (P =.0004). Multivariate analysis confirmed that the radiographic extent of disease and the site of disease were the only independent predictors of IFN-gamma production in HIV-negative and HIV-infected patients (P less than or equal to .001). We conclude that reduced IFN-gamma production by PBMCs is a marker of severe tuberculosis in both HIV-negative and HIV-infected patients with tuberculosis.