Pyrazinamide is not active in vitro against Mycobacterium avium complex.
Pyrazinamide is not active in vitro against Mycobacterium avium complex.
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吡嗪酰胺在体外对鸟分枝杆菌复合体没有活性。
DOI：
10.1164/arrd.1986.134.6.1287
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Lindholm-Levy,PJ
中科院分区：
文献类型：
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作者：
Heifets,LB;Iseman,MD;Crowle,AJ;Lindholm-Levy,PJ
菌株M.在结核病中，精细吡嗪酰胺酶通常在体外和体内可与吡嗪酰胺（PZA）结合。但我们发现33株M. aviumcomplex（MAC）均为吡嗪酰胺酶阳性，当通过放射性（BACTEC）方法在低pH值的7 H12肉汤中进行测试时，它们在体外对高浓度（100 µg/ml）的PZA具有耐药性。该药物对培养的正常人巨噬细胞内的这些细菌同样无效。我们的结论是，吡嗪酰胺酶试验是不适合的敏感性研究againstM。航空综合体根据我们的体外研究，支持早期的数据，我们认为PZA不适合治疗MAC疾病。
Strains ofM. tuberculosisthat elaborate pyrazinamidase are typically susceptiblein vitroandin vivoto pyrazinamide (PZA). However, we found that 33 strains ofM. aviumcomplex (MAC), all of which were pyrazinamidase-positive, were resistantin vitroto a high concentration (100 µg/ml) of PZA when tested at low pH in 7H12 broth by radiometric (BACTEC) method. The drug was equally ineffective against these bacteria within cultured normal human macrophages. We conclude that the pyrazinamidase test is not suitable for susceptibility studies againstM. aviumcomplex. On the basis of ourin vitrostudies, which support earlier data, we believe that PZA is not appropriate for therapy of MAC disease.