OTOTOXICITY OF GENTAMICIN IN MAN - SURVEY AND CONTROLLED ANALYSIS OF CLINICAL EXPERIENCE IN UNITED-STATES
OTOTOXICITY OF GENTAMICIN IN MAN - SURVEY AND CONTROLLED ANALYSIS OF CLINICAL EXPERIENCE IN UNITED-STATES
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DOI：
10.1093/infdis/124.supplement_1.s130
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发表时间：
1971-01-01
影响因子：
6.4
通讯作者：
ARCIERI, G
中科院分区：
文献类型：
--
作者：
JACKSON, GG;ARCIERI, G
庆大霉素的耳毒性很早就被认为是一种潜在的风险。从1962年至1969年在美国进行的临床试验中，共有72个疗程的治疗导致耳毒性，其中69名患者的70个疗程进行了综述。庆大霉素所致耳毒性可疑26例，可能44例。近期临床发病率为2.8%，真实发病率约为2%。在1966年至1969年期间的1484个疗程中，843个疗程与有耳毒性的疗程进行了比较。在匹配的亚组中，对14个变量进行逐步判别函数分析，并对发病率或平均值的差异进行统计学意义分析。肾功能损害是患者的主要特征。剂量(mg/kg/d)是治疗的主要因素，对于肾功能正常的患者来说，剂量是唯一有意义的因素。对于肾脏损害，使用耳毒性抗生素的既往病程和总剂量/公斤是重要的。治疗持续时间并不显著。年龄对此有不同的影响。耳毒性的风险不应妨碍庆大霉素的适当治疗。
Ototoxicity from gentamicin was recognized early as a potential risk. From clinical trials in the U.S. between 1962 and 1969, a total of 72 courses of treatment resulted in ototoxicity of which 70 courses in 69 patients were reviewed. Gentamicin-induced ototoxicity was doubtful in 26 cases, and probable in 44. The recent clinical incidence was 2.8%, the true incidence about 2%. Among 1,484 courses from 1966 to 1969 in which there was no ototoxicity, 843 were compared to those with ototoxicity. In matched subgroups, 14 variables were analyzed by stepwise discriminant function and for the statistical significance of differences in incidence or mean values. Impaired renal function was the dominant characteristic of patients. The dose (in mg/kg per day) was the major factor in treatment and the only significant one in patients with normal renal function. With renal impairment, previous courses with ototoxic antibiotics and the total dose/kg were important. The duration of treatment was not significant. Age had a variable effect. The risk of ototoxicity should not prevent proper treatment with gentamicin.