Quantitative study of the influence of swimming therapy on osteoporosis rat models based on synchrotron radiation computed tomogaphy
Quantitative study of the influence of swimming therapy on osteoporosis rat models based on synchrotron radiation computed tomogaphy
复制标题
基于同步辐射计算机断层扫描的游泳疗法对骨质疏松大鼠模型影响的定量研究
DOI：
10.1107/s160057751800276x
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发表时间：
2018
影响因子：
2.5
通讯作者：
Sun Jianqi
中科院分区：
文献类型：
--
作者：
Huang Liya;Xu Jun;Guo Han;Wang Yujie;Zhao Jun;Sun Jianqi
骨质疏松症是一种由多种原因引起的骨骼疾病，导致骨骼疼痛和骨折脆弱。治疗方法主要有营养疗法、运动疗法、药物疗法和手术疗法，其中以游泳等运动疗法最为有效。为探讨绝经后妇女最佳的游泳治疗方案，采用大鼠模型，研究了8周不同强度的游泳运动对绝经后妇女的影响。游泳训练结束后，解剖大鼠腰椎，进行同步辐射计算机断层扫描（SRCT）。基于获得的SRCT切片，对L4腰椎的骨小梁结构进行组织形态计量学分析和有限元分析。组织形态计量学分析表明，游泳可以缓解雌激素缺乏引起的骨强度下降，中等强度的游泳被发现有最显着的效果。
Osteoporosis is a bone disease with a variety of causes, leading to bone pain and fragility to fracture. Major treatment methods include nutrition therapy, exercise therapy, drug therapy and surgical treatment, among which exercise therapy, such as swimming, is the most effective. To investigate the optimal swimming therapy regime for postmenopausal women, the effects of eight weeks of different intensity swimming exercises were studied in rat models. After the swimming program, lumbar vertebrae were dissected from all the rats and scanned by synchrotron radiation computed tomography (SRCT). Histomorphometry analysis and finite-element analysis were carried out on the trabecular structure of the L4 lumbar based on the acquired SRCT slices. Histomorphometry analysis showed that swimming can alleviate the decrease in bone strength induced by estrogen deficiency, and moderate-intensity swimming was found to have the most significant effect.