Lipoic acid rescues DBA mice from early-onset age-related hearing impairment
Lipoic acid rescues DBA mice from early-onset age-related hearing impairment
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DOI：
10.1097/wnr.0b013e328308b338
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发表时间：
2008-08-27
期刊：
影响因子：
1.7
通讯作者：
Chung, Jong Woo
中科院分区：
文献类型：
--
作者：
Ahn, Joong Ho;Kang, Hun Hee;Chung, Jong Woo
We fed DBA mice with alpha-lipoic acid (100 mg/kg body weight/day), beginning 2, 4, or 8 weeks after birth. Hearing thresholds were measured weekly. At 12 weeks after birth, control mice not fed with alpha-lipoic acid showed significant hearing decreases at all frequencies. In contrast, mice fed with alpha-lipoic acid beginning at 2 weeks after birth showed significantly better hearing at all frequencies. Mice fed with alpha-lipoic acid beginning at 4 and 8 weeks after birth also showed significantly better hearing than control mice after they were fed with of.-lipoic acid. The stria vascularis of mice fed with alpha-lipoic acid showed reduced 8-oxoguanine residues in DNA and cytoplasm compared with that of control mice. Western blotting showed that the level of hypoxia-inducible factor-1 alpha was lower in mice fed with alpha-lipoic acid than in control mice. From these results, we suggest that alpha-lipoic acid prevented early-onset hearing impairment in DBA mice. NeuroReport 19:1265-1269 (c) 2008 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
