MILD FETAL LATERAL CEREBRAL VENTRICULOMEGALY - CLINICAL COURSE AND OUTCOME
MILD FETAL LATERAL CEREBRAL VENTRICULOMEGALY - CLINICAL COURSE AND OUTCOME
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DOI：
10.1016/0002-9378(91)90530-5
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发表时间：
1991-03-01
影响因子：
9.8
通讯作者：
BENACERRAF, BR
中科院分区：
文献类型：
--
作者：
BROMLEY, B;FRIGOLETTO, FD;BENACERRAF, BR
报告了 44 名产前诊断为轻度脑室扩大的胎儿的新生儿、病理结果和核型异常。 这 44 个胎儿中有 17 个（39%）有其他超声检查缺陷，5 个（12%）有异常核型。 五个妊娠被选择性流产，另外三个胎儿在新生儿期死亡。 其余 36 名活产新生儿中，有 26 名 (72%) 在 3 至 18 个月大时发育和临床均正常。 这 26 人中，有 21 人唯一的超声检查发现是轻度脑室扩大。 另外 10 名活产婴儿存在发育障碍，其中 10 名婴儿中有 5 名患有轻度脑室扩大，这是唯一的产前超声检查异常。 总之，这些数据表明，如文献报道，与脑室扩张较严重的胎儿相比，轻度脑室扩大的胎儿相关异常的发生率较低，预后较好。 大多数有轻度脑室扩大且核型正常的胎儿发育正常。
The neonatal, pathologic outcome and karyotypic abnormalities are reported for 44 fetuses with mild ventriculomegaly diagnosed antenatally. Seventeen of these 44 fetuses (39%) had other ultrasonographic defects, and five (12%) had abnormal karyotypes. Five pregnancies were electively aborted and three other fetuses died in the neonatal period. Twenty-six (72%) of the remaining 36 live-born neonates are developmentally and clinically normal at 3 to 18 months of age. Twenty-one of these 26 had isolated mild ventriculomegaly as the only ultrasonographic finding. The other 10 live-born infants are developmentally impaired, and five of these 10 had mild ventriculomegaly as the only prenatal ultrasonographic abnormality. In conclusion, these data show that fetuses with mild ventriculomegaly have a lower incidence of associated anomalies and a better outcome than fetuses with more severe ventricular dilatation, as reported in the literature. The majority of fetuses with mild ventriculomegaly as an isolated finding and a normal karyotype are developing normally.