Cephalosporin induced disulfiram-like reaction: a retrospective review of 78 cases.
Cephalosporin induced disulfiram-like reaction: a retrospective review of 78 cases.
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DOI：
10.9738/intsurg-d-13-00086.1
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发表时间：
2014-03
影响因子：
0.1
通讯作者：
Shi-yan Ren;Yuxia Cao;Xiu-wei Zhang;Shichen Jiao;Song-yi Qian;Peng Liu
中科院分区：
文献类型：
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作者：
Shi-yan Ren;Yuxia Cao;Xiu-wei Zhang;Shichen Jiao;Song-yi Qian;Peng Liu
同时摄入酒精和头孢菌素可能会引起双硫仑样反应；然而其致命后果并不为人所知。我们回顾性分析了 78 例头孢菌素引起的双硫仑样反应 (CIDLR) 患者。静脉注射抗生素前头孢菌素皮试呈阴性的患者被包括在内，对酒精或抗生素过敏的患者被排除在外。 78例患者的平均年龄为37.8±12.2（21-60）岁。 78例患者中，93.58%的患者为男性，70.51%的患者在使用抗生素后饮酒，29.49%的患者先饮酒，随后静脉注射抗生素；然而，这两组的发病率没有显着差异。所有患者均静脉注射抗生素。 78 名患者中有 5 名（6.41%）出现严重 CIDLR，病情过于紧急而无法成功抢救。总之，临床医生必须教育患者服用头孢菌素时不应饮酒，这一点很重要。此外，临床医生应记住，头孢菌素不应为任何酗酒者开具。
Concomitant ingestion of alcohol and cephalosporin may cause a disulfiram-like reaction; however its fatal outcomes are not commonly known. We retrospectively reviewed 78 patients who had cephalosporin induced disulfiram-like reaction (CIDLR). The patients who had a negative skin test to cephalosporin prior to intravenous antibiotics were included, and those who were allergic to either alcohol or antibiotics were excluded. The average age of 78 patients was 37.8±12.2 (21-60) years. Of the 78 patients, 93.58% of the patients were males, 70.51% of the patients consumed alcohol after use of antibiotics, and 29.49% patients consumed alcohol initially, followed by intravenous antibiotics; however, no significant difference of morbidity was observed in these two groups. All patients were administered antibiotics intravenously. Five of 78 patients (6.41%) developed severe CIDLR too urgently to be rescued successfully. In conclusion, it is important for clinicians to educate patients that no alcohol should be used if one is taking cephalosporin. Also, clinicians should keep in mind that cephalosporin should not be prescribed for any alcoholics.