Lipid mobilization with physiological atrial natriuretic peptide concentrations in humans
Lipid mobilization with physiological atrial natriuretic peptide concentrations in humans
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DOI：
10.1210/jc.2004-1953
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发表时间：
2005-06-01
影响因子：
5.8
通讯作者：
Jordan, J
中科院分区：
文献类型：
--
作者：
Birkenfeld, AL;Boschmann, M;Jordan, J
背景：药物浓度的心房利钠肽（ANP）刺激人体内脂质动员。目的：目的是确定血液动力学和代谢对生理相关ANP浓度的反应。设计：设计是一项人体生理学研究，于2004年进行。环境：本研究在某学术研究所进行。参与者：14名健康正常体重的男性（30 +/- 1.2岁）参加了这项研究。干预：静脉输注人ANP (h-ANP)，分别为6.25、12.5和25 ng/kg中心点min。主要观察指标：通过微透析研究局部血流、腹部脂肪组织和股骨骼肌糖脂代谢的变化。通过间接量热法监测能量消耗和底物氧化率的总体变化。结果：血清非酯化脂肪酸和甘油浓度升高与ANP血药浓度相关(r（2) = 0.86, r(2) = 0.76）。在脂肪组织中，甘油从53 +/- 6 mu mol/l增加到87 +/- 13 mu mol/l （P < 0.001）。在股骨骼肌中，甘油浓度没有变化，而乳酸与丙酮酸比值从91 +/- 23下降到32 +/- 4 （P < 0.001）。间接量热法显示，脂肪氧化增加（P < 0.05），同时碳水化合物氧化减少（P < 0.01），但总能量消耗没有变化。结论：ANP迅速刺激脂质动员和氧化，其血浆浓度在心力衰竭等情况下会遇到。利钠肽诱导的脂质动员可能与心脏恶病质有关。干扰利钠肽系统的药物应评估其潜在的代谢副作用。
Context: Atrial natriuretic peptide (ANP) in pharmacological concentrations stimulates lipid mobilization in humans.Objective: The objective was to determine the hemodynamic and metabolic response to physiologically relevant ANP concentrations.Design: The design was a human physiological study, conducted in 2004.Setting: The study was conducted at an academic research institute.Participants: Fourteen healthy normal-weight men ( 30 +/- 1.2 yr) participated in the study.Intervention: Intravenous infusion of human ANP (h-ANP) was administered at rates of 6.25, 12.5, and 25 ng/kg center dot min.Main Outcome Measures: We studied local changes in blood flow and glucose and lipid metabolism of abdominal sc adipose tissue and femoral skeletal muscle by microdialysis. Overall changes in energy expenditure and substrate oxidation rates were monitored by indirect calorimetry.Results: The increase in serum nonesterified fatty acids and glycerol concentrations were correlated with ANP plasma concentrations (r(2) = 0.86 and r(2) = 0.76, respectively). In adipose tissue, glycerol increased from 53 +/- 6 mu mol/liter to 87 +/- 13 mu mol/liter ( P < 0.001). In femoral skeletal muscle, glycerol concentrations did not change, whereas lactate-to-pyruvate ratio decreased from 91 +/- 23 to 32 +/- 4 ( P < 0.001). Indirect calorimetry indicated an increase in lipid oxidation ( P < 0.05) concomitantly with a decrease in carbohydrate oxidation ( P < 0.01), without changes in overall energy expenditure.Conclusions: ANP briskly stimulates lipid mobilization and oxidation at plasma concentrations that are encountered in conditions such as heart failure. Natriuretic-peptide induced lipid mobilization might contribute to cardiac cachexia. Drugs that interfere with the natriuretic peptide system should be evaluated for potential metabolic side effects.